Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK002023-05
Application #
2133687
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1991-07-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Pei, L; Melmed, S; Scheithauer, B et al. (1995) Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res 55:1613-6
Greenman, Y; Prager, D; Melmed, S (1995) The IGF-I receptor sub-membrane domain is intact in GH-secreting pituitary tumours. Clin Endocrinol (Oxf) 42:169-72
Webster, J; Prager, D; Melmed, S (1994) Insulin-like growth factor-1 activation of extracellular signal-related kinase-1 and -2 in growth hormone-secreting cells. Mol Endocrinol 8:539-44
Pei, L; Melmed, S; Scheithauer, B et al. (1994) H-ras mutations in human pituitary carcinoma metastases. J Clin Endocrinol Metab 78:842-6
Prager, D; Li, H L; Asa, S et al. (1994) Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant. Proc Natl Acad Sci U S A 91:2181-5
Prager, D; Li, H L; Yamasaki, H et al. (1994) Human insulin-like growth factor I receptor internalization. Role of the juxtamembrane domain. J Biol Chem 269:11934-7
Prager, D; Yamasaki, H; Weber, M M et al. (1994) Role of the insulin-like growth factors in regulating neuroendocrine function. Neurobiol Aging 15:569-72
Yamasaki, H; Prager, D; Melmed, S (1993) Structure-function of the human insulin-like growth factor-I receptor: a discordance of somatotroph internalization and signaling. Mol Endocrinol 7:681-5
Ejima, E; Rosenblatt, J D; Massari, M et al. (1993) Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV-I) tax and HTLV-II tax proteins. Blood 81:1017-24
Yamamoto, H; Prager, D; Yamasaki, H et al. (1993) Rat pituitary GC cell insulin-like growth factor-I receptor regulation. Endocrinology 133:1420-5

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