Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08DK002128-05
Application #
2133868
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1993-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Keates, A C; Castagliuolo, I; Cruickshank, W W et al. (2000) Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice. Gastroenterology 119:972-82
Castagliuolo, I; Keates, A C; Wang, C C et al. (1998) Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells. J Immunol 160:6039-45
Bliss Jr, C M; Golenbock, D T; Keates, S et al. (1998) Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun 66:5357-63
Keates, S; Hitti, Y S; Upton, M et al. (1997) Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology 113:1099-109
Castagliuolo, I; Kelly, C P; Qiu, B S et al. (1997) IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum. Am J Physiol 273:G333-41
Linevsky, J K; Pothoulakis, C; Keates, S et al. (1997) IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. Am J Physiol 273:G1333-40
Castagliuolo, I; Keates, A C; Qiu, B et al. (1997) Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc Natl Acad Sci U S A 94:4788-93
Keates, S; Keates, A C; Mizoguchi, E et al. (1997) Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol 273:G75-82
Kelly, C P (1996) Immune response to Clostridium difficile infection. Eur J Gastroenterol Hepatol 8:1048-53
Pothoulakis, C; Galili, U; Castagliuolo, I et al. (1996) A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile toxin A in rat colon. Gastroenterology 110:1704-12

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