I now propose to study the interaction of undernutrition, TH, and IGF-I in brain development. Focusing on early postnatal brain development in the mouse, the time when brain IGF-I expression, b) determine the influence of undernutrition on the expression of the type I IGF and related receptors and on IGF binding proteins, and finally, c) using transgenic mouse models of IGF-I availability, determine whether IGF-I can alter brain pathophysiology resulting from undernutrition. This research will extend my skills to a wide range of experimental approaches and to the techniques of molecular and cell biology. These experiences, together with a broadening of my basic science knowledge, should provide me with the tools to become an independent investigator and academician.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08DK002506-01
Application #
2370848
Study Section
Special Emphasis Panel (SRC)
Program Officer
Spinella, Giovanna M
Project Start
1997-09-01
Project End
2002-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pediatrics
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599