Specific aims of this study are (i) To determine whether liver DC convert from inert inducers of tolerance to potent immune-stimulators and mediators of inflammation in liver fibrosis, (ii) To determine the contributory role of DC in the pathogenesis of fibrosis and their direct role in HSC activation, (iii) To determine whether blockade of the immunogenic function of liver DC can mitigate the fibrogenic response to liver injury. In vitro and in vivo experiments in Aims 2 and 3 were affected by our loss of cell cultures, mice, and our lab shutdown and then relocation. An extension will help us complete the Aims of the grant which has been very fruitful till this point.
| Daley, Donnele; Mani, Vishnu R; Mohan, Navyatha et al. (2017) Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat Med 23:556-567 |
| Greco, Stephanie H; Torres-Hernandez, Alejandro; Kalabin, Aleksandr et al. (2016) Mincle Signaling Promotes Con A Hepatitis. J Immunol 197:2816-27 |
| Deutsch, M; Graffeo, C S; Rokosh, R et al. (2015) Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis 6:e1759 |
| Seifert, Lena; Deutsch, Michael; Alothman, Sara et al. (2015) Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways. Cell Rep 13:1909-1921 |
| Rao, Raghavendra; Graffeo, Christopher S; Gulati, Rishabh et al. (2014) Interleukin 17-producing ??T cells promote hepatic regeneration in mice. Gastroenterology 147:473-84.e2 |
| Zambirinis, Constantinos P; Ochi, Atsuo; Barilla, Rocky et al. (2013) Induction of TRIF- or MYD88-dependent pathways perturbs cell cycle regulation in pancreatic cancer. Cell Cycle 12:1153-4 |
| Henning, Justin R; Graffeo, Christopher S; Rehman, Adeel et al. (2013) Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology 58:589-602 |
| Rehman, Adeel; Hemmert, Keith C; Ochi, Atsuo et al. (2013) Role of fatty-acid synthesis in dendritic cell generation and function. J Immunol 190:4640-9 |
| Court, Helen; Amoyel, Marc; Hackman, Michael et al. (2013) Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest 123:4681-94 |
| Ochi, Atsuo; Graffeo, Christopher S; Zambirinis, Constantinos P et al. (2012) Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans. J Clin Invest 122:4118-29 |
Showing the most recent 10 out of 18 publications
