Abstract

The outlined experiments are proposed to (1) characterize how Ab1 is coupled to fibroblast growth factor receptor-1 (FGFR-1) signaling and (2) establish a role for FGFR-1 signaling through the Ab., Ras, and PlCgamma in lens development. In addition, an analysis of lens development using the transgeneic mice expressing the various alleles of Ab1 may identify specific protein interaction domains of Ab. involved in lens epithelial proliferation and differentiation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08EY000373-03
Application #
2668362
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Project Start
1997-03-01
Project End
2001-02-28
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Physiology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Nunes, I; Higgins, R D; Zanetta, L et al. (2001) c-abl is required for the development of hyperoxia-induced retinopathy. J Exp Med 193:1383-91