This is the candidate's first faculty position as Assistant Professor at the University of Texas-Houston. He learned basic research techniques as an NRSA Fellow, as part of a NIGMS training grant in trauma and burn research at the University of Texas Medical Branch. This resulted in the publication of manuscripts on microvascular permeability associated with lung injury and the use of extracorporeal life support (ECLS) techniques in trauma and burns. In his first year on faculty, he has developed both independent and collaborative projects at the Center for Lymphatic and Microvascular Studies at the University of Texas-Houston. He is co-director of the ECLS program and director of the Pediatric Trauma program at the University of Texas-Houston. The proposed project is a natural extension of the candidate's previous research experience and is directly related to his clinical expertise in the areas of trauma and ECLS. This proposed relationship between clinical scientist and bioengineers will allow the greatest potential for productive translational research. The focus of this project is the correlation of the degree of organ dysfunction and alterations in microvascular permeability with the degree of PMN/endothelial activation and interactions. Preliminary work has included the development of a canine model of increased microvascular permeability with ECLS. The University of Texas Health Science Center, Texas Medical Center and Rice University provide a unique scientific environment for young investigators. The candidate's sponsors are especially suited for the success of this project. Dr. Allen's expertise in microvascular barrier injury during cardiopulmonary bypass is central to the project. Dr. McIntire's expertise in PMN/endothelial/blood flow interactions will provide an important addition to the candidate's training.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08GM000675-01
Application #
2883929
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1999-09-30
Project End
2003-09-29
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Moore-Olufemi, Stacey D; Padalecki, Jeff; Olufemi, Shodimu E et al. (2009) Intestinal edema: effect of enteral feeding on motility and gene expression. J Surg Res 155:283-92
Radhakrishnan, Ravi S; Shah, Shinil K; Lance, Samuel H et al. (2009) Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation-induced intestinal edema. Crit Care Med 37:2946-52
Radhakrishnan, Ravi S; Radhakrishnan, Geetha L; Radhakrishnan, Hari R et al. (2008) Pretreatment with bone morphogenetic protein-7 (BMP-7) mimics ischemia preconditioning following intestinal ischemia/reperfusion injury in the intestine and liver. Shock 30:532-6
Desai, Ketaki V; Laine, Glen A; Stewart, Randolph H et al. (2008) Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. Am J Physiol Heart Circ Physiol 294:H2428-34
Cox Jr, Charles S; Radhakrishnan, Ravi; Villarrubia, Lindsey et al. (2008) Hypertonic saline modulation of intestinal tissue stress and fluid balance. Shock 29:598-602
Radhakrishnan, Ravi S; Radhakrishnan, Hari R; Xue, Hasen et al. (2007) Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Crit Care Med 35:538-43
Radhakrishnan, Ravi S; Lally, Pamela A; Lally, Kevin P et al. (2007) ECMO for meconium aspiration syndrome: support for relaxed entry criteria. ASAIO J 53:489-91
Fischer, Uwe M; Cox Jr, Charles S; Stewart, Randolph H et al. (2006) Impact of acute myocardial edema on left ventricular function. J Invest Surg 19:31-8
Uray, Karen S; Laine, Glen A; Xue, Hasan et al. (2006) Intestinal edema decreases intestinal contractile activity via decreased myosin light chain phosphorylation. Crit Care Med 34:2630-7
Radhakrishnan, Ravi S; Xue, Hasen; Moore-Olufemi, Stacey D et al. (2006) Hypertonic saline resuscitation prevents hydrostatically induced intestinal edema and ileus. Crit Care Med 34:1713-8

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