Abstract

description): The proposal consists of six Specific Aims and the experiments that will achieve these aims.
The aims are: 1. To determine the location(s) of G-CSF-R in the human placenta, at various stages of development, 2. To determine the function(s) of G-CSF in the human placenta, 3. To determine the location(s) of G-CSF production in the human placenta, at various stages development, 4. To determine the effect(s) of human intra-amniotic infection on placental production of G-CSF-R and G-CSF, 5. To quantify transplacental passage of G-CSF during term and preterm pregnancy in rats, and 6. To quantify transplacental passage of G-CSF during term and preterm normal and infected human gestations. The results will help clarify the location and function of placental G-CSF and G-CSF-R during human development, in health and during intra-amniotic infection, and the basic mechanistic events central to the pathogenesis of preterm labor and early-onset neonatal bacterial infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HD001180-02
Application #
2838647
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Ilekis, John V
Project Start
1997-12-15
Project End
2002-11-30
Budget Start
1998-12-01
Budget End
1999-11-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Florida
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Lu, Wenge; Gersting, Jason A; Maheshwari, Akhil et al. (2005) Developmental expression of chemokine receptor genes in the human fetus. Early Hum Dev 81:489-96
Maheshwari, Akhil; Lu, Wenge; Guida, Wayne C et al. (2005) IL-8/CXC ligand 8 survives neonatal gastric digestion as a result of intrinsic aspartyl proteinase resistance. Pediatr Res 57:438-44
Maheshwari, Akhil; Lacson, Atilano; Lu, Wenge et al. (2004) Interleukin-8/CXCL8 forms an autocrine loop in fetal intestinal mucosa. Pediatr Res 56:240-9
Kotto-Kome, Anne C; Calhoun, Darlene A; Montenegro, Raul et al. (2004) Effect of administering recombinant erythropoietin to women with postpartum anemia: a meta-analysis. J Perinatol 24:11-5
Condino, Adria A; Barleycorn, Aaron A; Lu, Wenge et al. (2004) Abnormal intestinal histology in neonates with congenital anomalies of the gastrointestinal tract. Biol Neonate 85:145-50
Gersting, Jason A; Christensen, Robert D; Calhoun, Darlene A (2004) Effects of enterally administering granulocyte colony-stimulating factor to suckling mice. Pediatr Res 55:802-6
Kotto-Kome, Anne C; Garcia, Maria G; Calhoun, Darlene A et al. (2004) Effect of beginning recombinant erythropoietin treatment within the first week of life, among very-low-birth-weight neonates, on ""early"" and ""late"" erythrocyte transfusions: a meta-analysis. J Perinatol 24:24-9
Maheshwari, Akhil; Christensen, Robert D; Calhoun, Darlene A (2003) ELR+ CXC chemokines in human milk. Cytokine 24:91-102
Lima-Rogel, Victoria; Calhoun, Darlene A; Maheshwari, Akhil et al. (2003) Tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors in neonates recovering from necrotizing enterocolitis. J Perinatol 23:200-4
Gersting, Jason A; Kotto-Kome, Catherine A; Du, Yan et al. (2003) Bioavailability of granulocyte colony-stimulating factor administered enterally to suckling mice. Pharmacol Res 48:643-7

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