During my years of training and practice, I have become convinced that a significant amount of scientific work has to be done in the field of clinical medicine to make its practice more objective and thus ultimately more useful. One of the areas that has interested me is regional myocardial perfusion and function and the inadequacy of coronary angiography in determining the significance of coronary stenosis. During my work with myocardial contrast agents, I became interested in their potential use for determining absolute regional myocardial perfusion. In addition, if the current limitations inherent in the quantitative assessment of regional myocardial function could be overcome, two-dimensional echocardiography would become an ideal and readily available tool for simultaneously assessing regional myocardial perfusion and function. This proposal deals in detail with what I think has to be investigated in order for myocardial contrast echocardiography to become a suitable modality for measuring regional perfusion and function. The relationship between contrast effect and blood flow has to be established; the effect of size and distribution of microbubbles on myocardial contrast effect has to be determined; the fate of microbubbles in the microvasculature has to be studied and the effect of these bubbles on the microvasculature has to be documented; the agent producing the least reactive hyperemic response has to be identified and its toxicity in intact animal and man studied. Finally, preliminary work has to be attempted in humans demonstrating significant advantages over currently available techniques of measuring myocardial blood flow. After developing a new algorithm for measuring regional myocardial function, studies involving flow-function relationships have to be performed.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL001833-03
Application #
3082215
Study Section
(SRC)
Project Start
1986-07-01
Project End
1991-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Kaul, S (1997) Myocardial contrast echocardiography: 15 years of research and development. Circulation 96:3745-60
Sabia, P J; Powers, E R; Ragosta, M et al. (1992) An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med 327:1825-31
Pollock, S G; Abbott, R D; Boucher, C A et al. (1992) Independent and incremental prognostic value of tests performed in hierarchical order to evaluate patients with suspected coronary artery disease. Validation of models based on these tests. Circulation 85:237-48
Kaul, S (1992) Clinical applications of myocardial contrast echocardiography. Am J Cardiol 69:46H-55H
Sklenar, J; Jayaweera, A R; Kaul, S (1992) A computer-aided approach for the quantitation of regional left ventricular function using two-dimensional echocardiography. J Am Soc Echocardiogr 5:33-40
Kaul, S; Glasheen, W P; Oliner, J D et al. (1991) Relation between anterograde blood flow through a coronary artery and the size of the perfusion bed it supplies: experimental and clinical implications. J Am Coll Cardiol 17:1403-13
Pollock, S G; Abbott, R D; Boucher, C A et al. (1991) A model to predict multivessel coronary artery disease from the exercise thallium-201 stress test. Am J Med 90:345-52
Sabia, P; Abbott, R D; Afrookteh, A et al. (1991) Importance of two-dimensional echocardiographic assessment of left ventricular systolic function in patients presenting to the emergency room with cardiac-related symptoms. Circulation 84:1615-24
Sabia, P; Afrookteh, A; Touchstone, D A et al. (1991) Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial infarction. A prospective study using two-dimensional echocardiography. Circulation 84:I85-92
Reed, D; Abbott, R D; Smucker, M L et al. (1991) Prediction of outcome after mitral valve replacement in patients with symptomatic chronic mitral regurgitation. The importance of left atrial size. Circulation 84:23-34

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