Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002731-05
Application #
2210460
Study Section
Special Emphasis Panel (SRC (FB))
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Pediatrics
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Abe, M K; Kartha, S; Karpova, A Y et al. (1998) Hydrogen peroxide activates extracellular signal-regulated kinase via protein kinase C, Raf-1, and MEK1. Am J Respir Cell Mol Biol 18:562-9
Karpova, A Y; Abe, M K; Li, J et al. (1997) MEK1 is required for PDGF-induced ERK activation and DNA synthesis in tracheal myocytes. Am J Physiol 272:L558-65
Girod, C E; Shin, D H; Hershenson, M B et al. (1996) p172: An alveolar type II and Clara cell specific protein with late developmental expression and upregulation by hyperoxic lung injury. Am J Respir Cell Mol Biol 14:538-47
Solway, J; Hershenson, M B (1995) Structural and functional abnormalities of the airways of hyperoxia-exposed immature rats. Chest 107:89S-93S
Naureckas, E T; Hershenson, M B; Abe, M K et al. (1995) Bronchoalveolar lavage fluid from immature rats with hyperoxia-induced airway remodeling is mitogenic for airway smooth muscle. Am J Respir Cell Mol Biol 12:268-74
Kelleher, M D; Abe, M K; Chao, T S et al. (1995) Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am J Physiol 268:L894-901
Kelleher, M D; Naureckas, E T; Solway, J et al. (1995) In vivo hyperoxic exposure increases cultured lung fibroblast proliferation and c-Ha-ras expression. Am J Respir Cell Mol Biol 12:19-26
Hershenson, M B; Chao, T S; Abe, M K et al. (1995) Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells. J Biol Chem 270:19908-13
Hershenson, M B; Abe, M K; Kelleher, M D et al. (1994) Recovery of airway structure and function after hyperoxic exposure in immature rats. Am J Respir Crit Care Med 149:1663-9
Abe, M K; Chao, T S; Solway, J et al. (1994) Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease. Am J Respir Cell Mol Biol 11:577-85

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