Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002768-05
Application #
2210529
Study Section
Research Training Review Committee (RTR)
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Rogers, C; Edelman, E R; Simon, D I (1998) A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits. Proc Natl Acad Sci U S A 95:10134-9
Simon, D I; Xu, H; Ortlepp, S et al. (1997) 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1. Arterioscler Thromb Vasc Biol 17:528-35
Wei, Y; Lukashev, M; Simon, D I et al. (1996) Regulation of integrin function by the urokinase receptor. Science 273:1551-5
Simon, D I; Rao, N K; Xu, H et al. (1996) Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 88:3185-94
Simon, D I; Mullins, M E; Jia, L et al. (1996) Polynitrosylated proteins: characterization, bioactivity, and functional consequences. Proc Natl Acad Sci U S A 93:4736-41
Simon, D I; Xu, H; Vaughan, D E (1995) Cathepsin D-like aspartyl protease activity mediates the degradation of tissue-type plasminogen activator/plasminogen activator inhibitor-1 complexes in human monocytes. Biochim Biophys Acta 1268:143-51
Simon, D I; Stamler, J S; Loh, E et al. (1995) Effect of nitric oxide synthase inhibition on bleeding time in humans. J Cardiovasc Pharmacol 26:339-42
Suh, T T; Holmback, K; Jensen, N J et al. (1995) Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev 9:2020-33