The vascular endothelium is important in maintaining hemostasis and vascular tone. Because of its unique location, it is readily exposed to circulating mediators, many of which influence fundamental cellular processes. Tumor necrosis factor is one of the inflammatory mediators that critically affects endothelial cell function. This proposal, entitled Prostaglandin Regulation in Vascular Endothelium, will explore an important aspect of endothelial cell physiology disrupted by tumor necrosis factor: the regulation of prostaglandin synthesis. This project will specifically examine the mechanism whereby tumor necrosis factor increases prostaglandin metabolism in endothelial cells. Tumor necrosis factor and prostaglandins play a role in a number of human conditions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002974-02
Application #
2210869
Study Section
Research Training Review Committee (RTR)
Project Start
1993-07-01
Project End
1998-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Utah
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Ferreira, P J; Bunch, T J; Albertine, K H et al. (2000) Circulating neutrophil concentration and respiratory distress in premature infants. J Pediatr 136:466-72
Logsdon, C D; Akana, S F; Meyer, C et al. (1987) Pancreatic acinar cell amylase gene expression: selective effects of adrenalectomy and corticosterone replacement. Endocrinology 121:1242-50