Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
3K08HL003601-01S1
Application #
2709111
Study Section
Special Emphasis Panel (ZHL1 (O1))
Project Start
1997-09-30
Project End
2000-09-29
Budget Start
1997-09-30
Budget End
1998-09-29
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Yaffe, M B; Leparc, G G; Lai, J et al. (2001) A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol 19:348-53
Datta, S R; Katsov, A; Hu, L et al. (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6:41-51
Durocher, D; Taylor, I A; Sarbassova, D et al. (2000) The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell 6:1169-82
Kanai, F; Marignani, P A; Sarbassova, D et al. (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J 19:6778-91
Bedford, M T; Frankel, A; Yaffe, M B et al. (2000) Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J Biol Chem 275:16030-6
Durocher, D; Smerdon, S J; Yaffe, M B et al. (2000) The FHA domain in DNA repair and checkpoint signaling. Cold Spring Harb Symp Quant Biol 65:423-31
Bedford, M T; Sarbassova, D; Xu, J et al. (2000) A novel pro-Arg motif recognized by WW domains. J Biol Chem 275:10359-69
Benzing, T; Yaffe, M B; Arnould, T et al. (2000) 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. J Biol Chem 275:28167-72
Trainor, C D; Ghirlando, R; Simpson, M A (2000) GATA zinc finger interactions modulate DNA binding and transactivation. J Biol Chem 275:28157-66
Bunnell, S C; Diehn, M; Yaffe, M B et al. (2000) Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem 275:2219-30

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