Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08MH067091-02
Application #
6691685
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Program Officer
Desmond, Nancy L
Project Start
2002-12-19
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$164,921
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Moberg, Paul J; Li, Mingyao; Kanes, Stephen J et al. (2012) Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q. Psychiatr Genet 22:286-9
Kelly, M P; Stein, J M; Vecsey, C G et al. (2009) Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Mol Psychiatry 14:398-415, 347
Kelly, Michele P; Cheung, York-Fong; Favilla, Christopher et al. (2008) Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression. Learn Mem 15:75-83
Kelly, Michele P; Isiegas, Carolina; Cheung, York-Fong et al. (2007) Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP. Neuropsychopharmacology 32:577-88
Moberg, Paul J; McGue, Colleen; Kanes, Stephen J et al. (2007) Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance. Schizophr Res 90:221-8
Kanes, S J; Tokarczyk, J; Siegel, S J et al. (2007) Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience 144:239-46
Gould, Thomas J; Bizily, Scott P; Tokarczyk, Jan et al. (2004) Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alpha. Neuropsychopharmacology 29:494-501