This proposal describes a 5-year training program for the development of an academic career in Endocrinology. The principal investigator has completed the required clinical training in Endocrinology and now will expand upon her scientific skills through a unique integration of interdepartmental resources. This program will promote the command of signal transduction biology as applied to the nervous system. Morris J. Birnbaum, M.D., Ph.D. will mentor the principal investigator's scientific development. Dr. Birnbaurn is a recognized leader in the field of signal transduction. He is a professor of Medicine and has trained numerous postdoctoral fellows and graduate students. To enhance the training, the program will enlist the expertise of Virginia M.-Y. Lee, Ph.D. Dr. Lee is the Director for the Center for Neurodegenerative Disease Research and is a leader in the field of Alzheimer's disease and dementia research. In addition, an advisory committee of highly regarded medical scientists will provide scientific and career advice. Research will focus on the signal transduction pathways regulating neuronal size.
The specific aims i nclude: 1) Determining the cellular mechanism by which Akt3 regulates brain size, 2) Determining the physiological importance of other isoforms of Akt in brain, and 3) Determining the molecular mechanism by which Akt controls brain size. This will be the first detailed analysis of isoform specific effects of Akt in neurons. In addition, this work will provide a better understanding of the signal transduction pathway regulated by Akt, a pathway altered in schizophrenia. The Medicine Department of the University of Pennsylvania provides an ideal setting for training physician scientists by incorporating expertise from diverse resources into customized programs. Such an environment maximizes the potential for the principal investigator to establish a scientific niche from which an academic career can be constructed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08MH072823-02
Application #
7094209
Study Section
Neurogenesis and Cell Fate Study Section (NCF)
Program Officer
Desmond, Nancy L
Project Start
2005-07-15
Project End
2007-03-04
Budget Start
2006-07-01
Budget End
2007-03-04
Support Year
2
Fiscal Year
2006
Total Cost
$103,510
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104