Dr. Van Voorhees' long-term research objective is to reduce the morbidity of depression during the adolescence through early, preventive intervention in primary care. Primary care physicians (PCP) currently lack a defined, efficacious behavioral intervention for adolescents with sub-threshold depressive symptoms who are at risk for progressing to major depression. The proposed training program will provide him with knowledge/skills to develop/evaluate preventive interventions. Dr. Van Voorhees (Principal Investigator) has already completed a pilot study of a prototype primary care/Web-based depression prevention intervention with late adolescents (age 18-24) that demonstrated favorable trends in three risk factors. This K-08 application proposes a three-step process to systematically redesign and evaluate the potential efficacy of each component of the intervention for younger adolescents age 14-18 in preparation for an anticipated efficacy study (RO-1). Results of a stakeholder marketing survey (Study I) will inform (motivation and feasibility factors) intervention redesign for younger adolescents (Study II) leading to a pilot randomized pilot efficacy evaluation of each component. Study I will identify the key motivation (attitudes, social norms and behavioral factors) and process (dose and socio-cultural relevance) factors that will influence feasibility and efficacy in the target age group. Informed by the survey results, Study II will revise the intervention to include a comprehensive approach to reducing modifiable risk factors including parent education/engagement and behavioral activation approaches (more suited to younger adolescents). Study will evaluate the potential efficacy of each of the components of the intervention. We will recruit and randomize the 100 participants into one of two study groups: (1) control group that will be given only the address of the Internet site and receive follow-up phone call to evaluate safety, and (2) full intervention (motivational program, Ml before and after internet components and 4 motivational phone calls). We will conduct intention to treat and completer analyses of three outcomes: 1) process (dose, time on site, exercise completion), 2) post-intervention mood (CES-D score) and post-intervention risk factor/resiliency measures. These results will lead directly to an RO-1 application. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08MH072918-03
Application #
7493489
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Goldstein, Amy B
Project Start
2006-09-01
Project End
2011-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
3
Fiscal Year
2008
Total Cost
$170,910
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Siddique, Juned; de Chavez, Peter J; Howe, George et al. (2018) Limitations in Using Multiple Imputation to Harmonize Individual Participant Data for Meta-Analysis. Prev Sci 19:95-108
Brown, C Hendricks; Brincks, Ahnalee; Huang, Shi et al. (2018) Two-Year Impact of Prevention Programs on Adolescent Depression: an Integrative Data Analysis Approach. Prev Sci 19:74-94
Brincks, Ahnalee; Montag, Samantha; Howe, George W et al. (2018) Addressing Methodologic Challenges and Minimizing Threats to Validity in Synthesizing Findings from Individual-Level Data Across Longitudinal Randomized Trials. Prev Sci 19:60-73
Hoerr, Jordan; Fogel, Joshua; Van Voorhees, Benjamin (2017) Ecological correlations of dietary food intake and mental health disorders. J Epidemiol Glob Health 7:81-89
Abuwalla, Zach; Kadhem, Zaynab; Gladstone, Tracy et al. (2017) Proposed model for the cultural adaptation of an Internet-based depression prevention intervention (CATCH-IT) for Arab adolescents. Int J Adolesc Med Health :
Mahoney, Nicholas; Gladstone, Tracy; DeFrino, Daniela et al. (2017) Prevention of Adolescent Depression in Primary Care: Barriers and Relational Work Solutions. Calif J Health Promot 15:1-12
Patel, Unnati; Sobowale, Kunmi; Fan, Jingyi et al. (2016) Cultural considerations for the adaptation of an Internet-based intervention for depression prevention in Mainland China. Int J Adolesc Med Health 29:
Richards, Katie; Marko-Holguin, Monika; Fogel, Joshua et al. (2016) RANDOMIZED CLINICAL TRIAL OF AN INTERNET-BASED INTERVENTION TO PREVENT ADOLESCENT DEPRESSION IN A PRIMARY CARE SETTING (CATCH-IT): 2.5-YEAR OUTCOMES. J Evid Based Psychother 16:113-134
Gladstone, Tracy G; Marko-Holguin, Monika; Rothberg, Phyllis et al. (2015) An internet-based adolescent depression preventive intervention: study protocol for a randomized control trial. Trials 16:203
Van Voorhees, Benjamin W; Gladstone, Tracy; Cordel, Stephanie et al. (2015) Development of a technology-based behavioral vaccine to prevent adolescent depression: A health system integration model. Internet Interv 2:303-313

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