Previous studies of trauma related spinal cord injury patients (SCI) suggest that nearly 50% of these patients sustain a concomitant closed head injury (CHI). Early reports suggest that some of these patients demonstrate cognitive deficits within the first year after injury. However, these studies are hampered by several problems, including the lack of controls and the inability to administer screening tests requiring hand function to this population. This study will evaluate neuropsychological deficits in newly injured spinal cord injury patients and relate this to the incidence and severity of medical complications at one year after injury. Prevalence Study: The incidence and duration of loss of consciousness and traumatic amnesia will be evaluated in newly injured spinal cord injury patients. These patients will undergo a standard battery of neuropsychological testing, which is predominantly motor free, to evaluate deficits in orientation, memory, abstract reasoning and problem solving. A control group matched for age, sex, level of education and geographic location will be utilized to develop mental performance ranges on these tests. Premorbid information regarding other factors which may be related to cognitive dysfunction will also be assessed. This study will test the hypothesis that the majority of patients with evidence of cognitive dysfunction have sustained a concurrent CHI. Medical Morbidity: All patients will be reviewed at one year following discharge from initial rehabilitative care to determine the incidence and severity of medical morbidities associated with SCI. It is expected that patients with associated cognitive dysfunction are at greater risk for the development of medical complications during this one year period. Such findings might warrant modification of patient education or length of stay during initial hospitalization as well as the frequency and form of outpatient follow-up for these patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08NS001120-03
Application #
3083839
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1986-07-01
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1990-06-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Hurvitz, E A; Mandac, B R; Davidoff, G et al. (1992) Risk factors for heterotopic ossification in children and adolescents with severe traumatic brain injury. Arch Phys Med Rehabil 73:459-62
Davidoff, G N; Roth, E J; Richards, J S (1992) Cognitive deficits in spinal cord injury: epidemiology and outcome. Arch Phys Med Rehabil 73:275-84
Davidoff, G N; Lampman, R M; Westbury, L et al. (1992) Exercise testing and training of persons with dysvascular amputation: safety and efficacy of arm ergometry. Arch Phys Med Rehabil 73:334-8
Davidoff, G; Werner, R; Waring, W (1991) Compressive mononeuropathies of the upper extremity in chronic paraplegia. Paraplegia 29:17-24
Davidoff, G N; Keren, O; Ring, H et al. (1991) Acute stroke patients: long-term effects of rehabilitation and maintenance of gains. Arch Phys Med Rehabil 72:869-73
Davidoff, G N; Ditunno, J F; Findley, T W et al. (1991) Elements of academic productivity: a comparison of PM&R units versus other clinical science units. Arch Phys Med Rehabil 72:874-6
Finestone, H M; Lampman, R M; Davidoff, G N et al. (1991) Arm ergometry exercise testing in patients with dysvascular amputations. Arch Phys Med Rehabil 72:15-9
Davidoff, G N; Roth, E J; Haughton, J S et al. (1990) Cognitive dysfunction in spinal cord injury patients: sensitivity of the Functional Independence Measure subscales vs neuropsychologic assessment. Arch Phys Med Rehabil 71:326-9
Roth, E; Davidoff, G; Thomas, P et al. (1989) A controlled study of neuropsychological deficits in acute spinal cord injury patients. Paraplegia 27:480-9
Davidoff, G; Werner, R; Cremer, S et al. (1989) Predictive value of the three-phase technetium bone scan in diagnosis of reflex sympathetic dystrophy syndrome. Arch Phys Med Rehabil 70:135-7

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