Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08NS001724-03
Application #
2259834
Study Section
NST-2 Subcommittee (NST)
Project Start
1994-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Neystat, M; Lynch, T; Przedborski, S et al. (1999) Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease. Mov Disord 14:417-22
Przedborski, S; Jackson-Lewis, V (1998) Mechanisms of MPTP toxicity. Mov Disord 13 Suppl 1:35-8
Jakowec, M W; Jackson-Lewis, V; Chen, X et al. (1998) The postnatal development of AMPA receptor subunits in the basal ganglia of the rat. Dev Neurosci 20:19-33
Sterneck, E; Paylor, R; Jackson-Lewis, V et al. (1998) Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta. Proc Natl Acad Sci U S A 95:10908-13
Przedborski, S; Jackson-Lewis, V (1998) Experimental developments in movement disorders: update on proposed free radical mechanisms. Curr Opin Neurol 11:335-9
Kostic, V; Jackson-Lewis, V; de Bilbao, F et al. (1997) Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 277:559-62
Mena, M A; Khan, U; Togasaki, D M et al. (1997) Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture. J Neurochem 69:21-33
Takahashi, N; Miner, L L; Sora, I et al. (1997) VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proc Natl Acad Sci U S A 94:9938-43
Przedborski, S; Jackson-Lewis, V; Yokoyama, R et al. (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci U S A 93:4565-71
Przedborski, S; Dhawan, V; Donaldson, D M et al. (1996) Nigrostriatal dopaminergic function in familial amyotrophic lateral sclerosis patients with and without copper/zinc superoxide dismutase mutations. Neurology 47:1546-51

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