Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08NS001732-03
Application #
2259855
Study Section
NST-2 Subcommittee (NST)
Project Start
1994-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Quinones-Hinojosa, Alfredo; Malek, Junaid Y; Ames 3rd, Adelbert et al. (2003) Metabolic effects of hypothermia and its neuroprotective effects on the recovery of metabolic and electrophysiological function in the ischemic retina in vitro. Neurosurgery 52:1178-86; discussion 1186-7
Sakakibara, Yohtaro; Mitha, Alim P; Ayoub, Issam A et al. (2002) Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats. Brain Res 931:68-73
Sakakibara, Y; Mitha, A P; Ogilvy, C S et al. (2000) Post-treatment with nicotinamide (vitamin B(3)) reduces the infarct volume following permanent focal cerebral ischemia in female Sprague-Dawley and Wistar rats. Neurosci Lett 281:111-4
Mokudai, T; Ayoub, I A; Sakakibara, Y et al. (2000) Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats. Stroke 31:1679-85
Lee, E J; Ayoub, I A; Harris, F B et al. (1999) Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats. J Neurosci Res 58:442-8
Ayoub, I A; Lee, E J; Ogilvy, C S et al. (1999) Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats. Neurosci Lett 259:21-4
Maynard, K I; Quinones-Hinojosa, A; Ogilvy, C S (1998) Magnesium plus mexiletine inhibit energy usage and protect retinas against ischemia. Neuroreport 9:4141-4
Smrcka, M; Ogilvy, C S; Crow, R J et al. (1998) Induced hypertension improves regional blood flow and protects against infarction during focal ischemia: time course of changes in blood flow measured by laser Doppler imaging. Neurosurgery 42:617-24;discussion 624-5
Maynard, K I; Arango, P M; Chen, D et al. (1998) Acetylsalicylate administered during simulated ischemia reduces the recovery of neuronal function in the in vitro rabbit retina. Neurosci Lett 249:159-62
Maynard, K I; Chen, D; Arango, P M et al. (1996) Nitric oxide produced during ischemia improves functional recovery in the rabbit retina. Neuroreport 8:81-5