This Physician Scientist Award is designed with a two-fold purpose. First to develop the applicant into a skilled researcher with experience in basic scientific research and secondly to expand existing knowledge of the specific physiologic response of trabecular bone to an orthopaedic implant model of known mechanical stress. Trabecular bone has an important relationship to orthopaedic implants in total joint arthroplasty. Most work on bone response and remodelling has dealt with cortical bone. In total joints, the stresses may be passed directly to trabecular bone, and its response to this stress may have a great deal of effect on loosening, the dominant factor in implant failure. Work currently under way has shown a definite change in trabecular bone response with time and type of mechanical stress. To the simplest observations, this response has included changes in trabecular size and orientation. A careful description of the physiologic response of trabecular bone to an applied stress at the cellular level is lacking and needed to further our understanding. These same studies need to be undertaken in osteopenic bone to more fully simulate the trabecular response of the elderly total joint population. This is the focus of the second phase of this proposal and includes detailed microscopic and histochemical analysis of the bone. In a constantly aging society with known loss of trabecular bone substance, these responses may contain valuable clues both to prevent implant loosening, and arrest or reverse trabecular bone loss.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Physician Scientist Award (K11)
Project #
5K11AR001793-03
Application #
3085615
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1987-09-01
Project End
1992-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Chiang, E H; Adler, R S; Meyer, C R et al. (1994) Quantitative assessment of surface roughness using backscattered ultrasound: the effects of finite surface curvature. Ultrasound Med Biol 20:123-35
Dedrick, D K; Goldstein, S A; Brandt, K D et al. (1993) A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rheum 36:1460-7
Adler, R S; Dedrick, D K; Laing, T J et al. (1992) Quantitative assessment of cartilage surface roughness in osteoarthritis using high frequency ultrasound. Ultrasound Med Biol 18:51-8
Dedrick, D K; Mase, C; Ranger, W et al. (1992) The effects of intraosseous infusion on the growth plate in a nestling rabbit model. Ann Emerg Med 21:494-7
Dedrick, D K; Goulet, R; Huston, L et al. (1991) Early bone changes in experimental osteoarthritis using microscopic computed tomography. J Rheumatol Suppl 27:44-5