Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Physician Scientist Award (K11)
Project #
5K11CA001760-04
Application #
2084430
Study Section
Cancer Institutional Fellowship Review Committee (CT)
Project Start
1993-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Endo, S; Zeng, Q; Burke, N A et al. (2000) TGF-alpha antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo. Gene Ther 7:1906-14
Grandis, J R; Drenning, S D; Zeng, Q et al. (2000) Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A 97:4227-32
Rubin Grandis, J; Zeng, Q; Drenning, S D (2000) Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer. Laryngoscope 110:868-74
Grandis, J R; Chakraborty, A; Zeng, Q et al. (1998) Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem 69:55-62
Grandis, J R; Drenning, S D; Chakraborty, A et al. (1998) Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest 102:1385-92
Drenning, S D; Marcovitch, A J; Johnson, D E et al. (1998) Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res 4:2913-21
Rubin Grandis, J; Tweardy, D J; Melhem, M F (1998) Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma. Clin Cancer Res 4:13-20
Rubin Grandis, J; Melhem, M F; Gooding, W E et al. (1998) Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90:824-32
He, Y; Zeng, Q; Drenning, S D et al. (1998) Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst 90:1080-7
Grandis, J R; Zeng, Q; Drenning, S D et al. (1998) Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line. Int J Oncol 13:375-8

Showing the most recent 10 out of 13 publications