The following grant application is for a Physician Scientist Award which will provide five years of research support for the candidate, who is currently a second year Research Fellow in the Division of Endocrinology and metabolism at Emory University School of Medicine. The candidate has been affiliated with the lab of the sponsor for eighteen months. The Sponsor holds an appointment in the Department of Biochemistry and is a member of the interdepartmental Endocrine Group at Emory. The period of support is divided into phase I, a two year period basic science course work, didactic training and closely supervised research efforts; and phase II, a three year period of intensified research effort and continued close interaction with the Sponsor, with emphasis on a transition towards an independent research career. The research project proposed is an extension of the clinical interest in Noninsulin Dependent Diabetes Mellitus that the Candidate developed during House staff training. Research will initially focus on the evaluation of the long-chain base sphingosine, which the candidate has shown to be a potent inhibitor of insulin action, as a potential probe of the mechanisms of insulin signal transduction. Studies will then focus on the mechanism of insulin stimulated changes in hexose transporter distribution and activity. Through studies supported by the Physician Scientist Award, the candidate hopes to lay the foundation for an academic career in medicine.
| Pao, C I; Zhu, J L; Robertson, D G et al. (1995) Transcriptional regulation of the rat insulin-like growth factor-I gene involves metabolism-dependent binding of nuclear proteins to a downstream region. J Biol Chem 270:24917-23 |
| Pao, C I; Farmer, P K; Begovic, S et al. (1993) Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein 1 gene transcription by hormones and provision of amino acids in rat hepatocytes. Mol Endocrinol 7:1561-8 |
| Phillips, L S; Robertson, D G (1993) Insulin-like growth factors and non-islet cell tumor hypoglycemia. Metabolism 42:1093-101 |
| Glass, D B; Robertson, D G; Xu, T S et al. (1991) Chemical synthesis, initial conformational studies, and activity of rat steroidogenesis activator peptide and a truncated analog. Endocr Res 17:307-26 |
| Robertson, D G; Perry, D; Lambeth, J D (1991) Inhibition of mitochondrial cholesterol side-chain cleavage by structural analogs of cholesterol sulfate. Endocr Res 17:297-306 |
