Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (K11)
Project #
5K11DK002076-05
Application #
2133750
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Chen, Frank; Ma, Lin; Dawson, Paul A et al. (2003) Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem 278:19909-16
Chen, Frank; Ma, Lin; Sartor, R Balfour et al. (2002) Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation. Gastroenterology 123:2005-16
Al-Ansari, Namir; Xu, Guorong; Kollman-Bauerly, Katie et al. (2002) Analysis of the effect of intestinal resection on rat ileal bile Acid transporter expression and on bile Acid and cholesterol homeostasis. Pediatr Res 52:286-91
Chen, F; Ma, L; Al-Ansari, N et al. (2001) The role of AP-1 in the transcriptional regulation of the rat apical sodium-dependent bile acid transporter. J Biol Chem 276:38703-14
Shneider, B L (2001) Intestinal bile acid transport: biology, physiology, and pathophysiology. J Pediatr Gastroenterol Nutr 32:407-17
Shih, D Q; Bussen, M; Sehayek, E et al. (2001) Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet 27:375-82
Arrese, M; Trauner, M; Sacchiero, R J et al. (1998) Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter. Hepatology 28:1081-7
Coppola, C P; Gosche, J R; Arrese, M et al. (1998) Molecular analysis of the adaptive response of intestinal bile acid transport after ileal resection in the rat. Gastroenterology 115:1172-8
Shneider, B L; Setchell, K D; Crossman, M W (1997) Fetal and neonatal expression of the apical sodium-dependent bile acid transporter in the rat ileum and kidney. Pediatr Res 42:189-94
Shneider, B L; Thevananther, S; Moyer, M S et al. (1997) Cloning and characterization of a novel peptidase from rat and human ileum. J Biol Chem 272:31006-15

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