Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (K11)
Project #
5K11DK002101-05
Application #
2133794
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Varilek, G W; Yang, F; Lee, E Y et al. (2001) Green tea polyphenol extract attenuates inflammation in interleukin-2-deficient mice, a model of autoimmunity. J Nutr 131:2034-9
Colson, A O; Perlman, J H; Jinsi-Parimoo, A et al. (1998) A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation. Mol Pharmacol 54:968-78
Colson, A O; Perlman, J H; Smolyar, A et al. (1998) Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor. Biophys J 74:1087-100
Perlman, J H; Colson, A O; Jain, R et al. (1997) Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone. Biochemistry 36:15670-6
Perlman, J H; Colson, A O; Wang, W et al. (1997) Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor. J Biol Chem 272:11937-42
Laakkonen, L J; Guarnieri, F; Perlman, J H et al. (1996) A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Novel mixed mode Monte Carlo/stochastic dynamics simulations of the complex between TRH and TRH receptor. Biochemistry 35:7651-63
Perlman, J H; Laakkonen, L J; Guarnieri, F et al. (1996) A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Biochemistry 35:7643-50
Laakkonen, L; Li, W; Perlman, J H et al. (1996) Restricted analogues provide evidence of a biologically active conformation of thyrotropin-releasing hormone. Mol Pharmacol 49:1092-6
Perlman, J H; Laakkonen, L; Osman, R et al. (1995) Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotropin-releasing hormone receptor. Mol Pharmacol 47:480-4
Perlman, J H; Thaw, C N; Laakkonen, L et al. (1994) Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. J Biol Chem 269:1610-3

Showing the most recent 10 out of 12 publications