Structural Basis of the Interaction of Vwf and Fviii

Foster, Paul A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Physician Scientist Award (K11)
• Project #: 5K11HL002064-03
• Application #: 3087511
• Study Section: Research Manpower Review Committee (MR)
• Project Start: 1988-08-01
• Project End: 1991-03-31
• Budget Start: 1990-08-01
• Budget End: 1991-03-31
• Support Year: 3
• Fiscal Year: 1990

Institution

• Name: Scripps Research Institute
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Kroner, P A; Foster, P A; Fahs, S A et al. (1996) The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor. Blood 87:1013-21

Foster, P A; Fulcher, C A; Houghten, R A et al. (1990) Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine. Blood 75:1999-2004

Foster, P A; Fulcher, C A; Houghten, R A et al. (1990) A synthetic factor VIII peptide of eight amino acid residues (1677-1684) contains the binding region of an anti-factor VIII antibody which inhibits the binding of factor VIII to von Willebrand factor. Thromb Haemost 63:403-6

Foster, P A; Fulcher, C A; Houghten, R A et al. (1990) A murine monoclonal anti-factor VIII inhibitory antibody and two human factor VIII inhibitors bind to different areas within a twenty amino acid segment of the acidic region of factor VIII heavy chain. Blood Coagul Fibrinolysis 1:9-15