This revised competing renewal proposal seeks support to continue a highly successful, NIA-funded Mentored Clinical Scientist Development Program Award. The program represents a major, multidisciplinary and interdepartmental collaboration among the medical school, school of public health, as well as the affiliated institutions in the Longwood Medical Area and around Boston. We have increased our efforts at recruiting candidates widely, including those who are members of under-represented minorities in aging research, and those who are from other medical schools including schools of osteopathy. We have provided information on eight superb prospective trainee candidates of which five are women, three are African American, one is Hispanic, and one is a doctor of osteopathy working with underserved elderly (including Native Americans) in rural Maine. Many of these candidates are interested in pursuing research in public and social medicine, especially the care of minority elderly in the underserved, inner-city and underserved rural communities of America. The proposed Program is designed to support and enhance research experience in several interrelated gerontologic disciplines. Six specific areas will be emphasized. These are (1) cardiovascular disease, (2) cell proliferation disorders, (3) neurodegenerative disease and dementia, (4) endocrine/renal dysfunction, (5) geriatric syndromes, and (6) public health. More than 50 experienced, well-funded faculty scientists (20 of whom are women), many of whom are established gerontologic investigators, will serve as potential primary or secondary mentors for the clinician scientist trainees. A dual mentoring system has been implemented to ensure ongoing exposure to gerontologic/geriatric expertise and orientation. Ultimately, we plan to develop the trainees into clinician investigators who can facilitate the translation of important research findings into improved care for all older Americans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12AG000294-18
Application #
6661307
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Premen, Andre J
Project Start
1985-08-01
Project End
2005-06-30
Budget Start
2003-09-01
Budget End
2005-06-30
Support Year
18
Fiscal Year
2003
Total Cost
$469,905
Indirect Cost
Name
Harvard University
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Mendiratta, P; Tilford, J M; Prodhan, P et al. (2012) Trends in percutaneous endoscopic gastrostomy placement in the elderly from 1993 to 2003. Am J Alzheimers Dis Other Demen 27:609-13
Sorond, Farzaneh A; Serrador, Jorge M; Jones, Richard N et al. (2009) The sit-to-stand technique for the measurement of dynamic cerebral autoregulation. Ultrasound Med Biol 35:21-9
Sorond, Farzaneh A; Shaffer, Michele L; Kung, Andrew L et al. (2009) Desferroxamine infusion increases cerebral blood flow: a potential association with hypoxia-inducible factor-1. Clin Sci (Lond) 116:771-9
Rudolph, James L; Sorond, Farzaneh A; Pochay, Val E et al. (2009) Cerebral hemodynamics during coronary artery bypass graft surgery: the effect of carotid stenosis. Ultrasound Med Biol 35:1235-41
Sorond, Farzaneh A; Schnyer, David M; Serrador, Jorge M et al. (2008) Cerebral blood flow regulation during cognitive tasks: effects of healthy aging. Cortex 44:179-84
Lao, Qi Zong; Kobrinsky, Evgeny; Harry, Jo Beth et al. (2008) New Determinant for the CaVbeta2 subunit modulation of the CaV1.2 calcium channel. J Biol Chem 283:15577-88
Ravindran, Arippa; Lao, Qi Zong; Harry, Jo Beth et al. (2008) Calmodulin-dependent gating of Ca(v)1.2 calcium channels in the absence of Ca(v)beta subunits. Proc Natl Acad Sci U S A 105:8154-9
Rudolph, James L; Salow, Marci J; Angelini, Michael C et al. (2008) The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med 168:508-13
Xie, Zhongcong; Dong, Yuanlin; Maeda, Uta et al. (2007) RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem 282:4318-25
Culley, Deborah J; Xie, Zhongcong; Crosby, Gregory (2007) General anesthetic-induced neurotoxicity: an emerging problem for the young and old? Curr Opin Anaesthesiol 20:408-13

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