Yale University School of Medicine is seeking to be one of the centers of excellence in diabetes training that will allow bright young pediatricians to establish academic careers in pediatric endocrinology as independent investigators in diabetes. In this K12 application, we are requesting 3 Physician Scientist stipends per year for 5 years. Yale has an impressive array of resources that will support this program, including a DERC, separate Children and Adult GCRC's, JDRF Center for the Study of Hypoglycemia, Pediatric Pharmacology Research Unit, Child Health Research Center, Mouse Metabolic Phenotyping Center, NMR Center and a new 450,000 sq. foot clinical science research facility. The Program Director and faculty mentors are highly respected and productive investigators with extensive peer-reviewed grant support to fund trainees' projects. Our faculty has a long history of extensive collaborations and an outstanding track record in the career development of young physician scientists. Our physician scientist trainees can choose between five major areas of research training (pathophysiology of T1 and T2 DM, hypoglycemia/neurobiology, immunobiology of diabetes and behavioral/psychosocial aspects of diabetes) and 4-6 primary and secondary mentors within each area. A centerpiece of our didactic studies is the K30 Investigative Medicine Program that combines mentored research training with a rigorous curriculum of required and elective courses along two pathways, i.e. patient-oriented and disease-oriented. Successful completion of course work and thesis project will allow trainees to receive a Ph.D. that is awarded through the Department of Medicine. Alternative curricula for non-Ph.D, candidates include the Quantitative Clinical Epidemiology course offered by the Robert Wood Johnson Clinical Scholars Program and the Seminar Series for Young Investigators offered by the Yale Child Health Research Center. The formation of a """"""""consortium"""""""" of three centers of excellence in diabetes research training will allow us to collaborate in training efforts as well as in innovative recruitment effort. Dr. James Gavin, former President of the ADA and incoming President of Morehouse School of Medicine, has indicated his interest in linking his school to our program in the recruitment of African American trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12DK063709-03
Application #
6777063
Study Section
Special Emphasis Panel (ZDK1-GRB-B (O2))
Program Officer
Hyde, James F
Project Start
2002-09-30
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
3
Fiscal Year
2004
Total Cost
$428,852
Indirect Cost
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Cengiz, Eda; Tamborlane, William V; Martin-Fredericksen, Melody et al. (2010) Early pharmacokinetic and pharmacodynamic effects of mixing lispro with glargine insulin: results of glucose clamp studies in youth with type 1 diabetes. Diabetes Care 33:1009-12
Cengiz, Eda; Tamborlane, William V (2009) A tale of two compartments: interstitial versus blood glucose monitoring. Diabetes Technol Ther 11 Suppl 1:S11-6
Weinzimer, Stuart A; Steil, Garry M; Swan, Karena L et al. (2008) Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas. Diabetes Care 31:934-9
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Weiss, Ram; Cali, Anna M; Dziura, James et al. (2007) Degree of obesity and glucose allostasis are major effectors of glucose tolerance dynamics in obese youth. Diabetes Care 30:1845-50
Weinzimer, Stuart A; Swan, Karena L; Sikes, Kristin A et al. (2006) Emerging evidence for the use of insulin pump therapy in infants, toddlers, and preschool-aged children with type 1 diabetes. Pediatr Diabetes 7 Suppl 4:15-9
Burgert, Tania S; Taksali, Sara E; Dziura, James et al. (2006) Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab 91:4287-94
Springer, Dena; Dziura, James; Tamborlane, William V et al. (2006) Optimal control of type 1 diabetes mellitus in youth receiving intensive treatment. J Pediatr 149:227-32
Tamborlane, William V; Sikes, Kristin A; Steffen, Amy T et al. (2006) Continuous subcutaneous insulin infusion (CSII) in children with type 1 diabetes. Diabetes Res Clin Pract 74 Suppl 2:S112-5
Burgert, T S; Dziura, J; Yeckel, C et al. (2006) Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors. Int J Obes (Lond) 30:273-80

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