The overall theme of the BIRCWH Center has been to emphasize a fundamental approach to the diseases of women that include the disciplines of developmental biology, molecular genetics and cell biology, behavioral science, cardiovascular science, acquired immune deficiency disease, aging and its problems as it affects women, as well as translational and clinical investigative research. All of the proposed faculty mentors will be able to provide training to allow the BIRCWH Scholars to establish their own independent, fundable research programs applicable to the clinical problems of women. At present we have three Scholars; from Urology, Medicine (Rheumatology), and Obstetrics and Gynecology. All three are women, and one a Puerto Rican. All of them have been awarded peer-reviewed federal grants; one an R-01, one a VA Career Development Award, and one an R-21. All of this was possible because they were able to generate preliminary data while receiving BIRCWH grant support. One of our Scholars who graduated is an African-American who obtained an NIH K-01 award and is at present an Assistant Professor in the Department of Medicine (Cardiology). The impact of the BIRCWH Center has already extended beyond the New Program Development Awardees and has stimulated initiation and collaboration of research related to Women's Health between various faculty members transcending departmental boundaries and facilitated the recruitment of medical students, house officers, and fellows into investigative basic and clinical research related to Women's Health. In view of the multidisciplinary approach of the activities of the already established BIRCWH Center, and the fact that our institution is one of the national sites for the Women's Reproductive Health Research Career Development Center, as well as being awarded the National Center of Excellence Contract by the Office of Women's Health/Public Health Service, the foundations have been laid for the future creation of a """"""""Women's Health Research Center"""""""" encompassing research, training, and teaching in matters related to Women's Health. The establishment of the BIRCWH and WRHR Centers has also helped our affiliated minority institution; the King/Drew Medical School. For example, the King/Drew Medical School and the David Geffen School of Medicine at UCLA applied for and received a grant entitled """"""""Drew-UCLA Reproductive Sciences Research Center: Biologic Effects of Androgens in Men and Women"""""""". The BIRCWH grant will help train scientist from various disciplines to do research in Women's Health, which is an underserved area in public health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD001400-07
Application #
7117696
Study Section
Special Emphasis Panel (ZRG1-EMNR-J (50))
Program Officer
Lamar, Charisee A
Project Start
2000-08-30
Project End
2010-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
7
Fiscal Year
2006
Total Cost
$454,062
Indirect Cost
Name
University of California Los Angeles
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Calkins, Kara L; Thamotharan, Shanthie; Dai, Yun et al. (2018) Early dietary restriction in rats alters skeletal muscle tuberous sclerosis complex, ribosomal s6 and mitogen-activated protein kinase. Nutr Res 54:93-104
Calkins, Kara L; Havranek, Thomas; Kelley-Quon, Lorraine I et al. (2017) Low-Dose Parenteral Soybean Oil for the Prevention of Parenteral Nutrition-Associated Liver Disease in Neonates With Gastrointestinal Disorders. JPEN J Parenter Enteral Nutr 41:404-411
Calkins, Kara L; Sanchez, Lauren A; Tseng, Chi-Hong et al. (2016) Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates. JPEN J Parenter Enteral Nutr 40:226-34
Levit, Orly L; Calkins, Kara L; Gibson, L Caroline et al. (2016) Low-Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates. JPEN J Parenter Enteral Nutr 40:374-82
Calkins, Kara L; Dunn, James C Y; Shew, Stephen B et al. (2014) Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil. JPEN J Parenter Enteral Nutr 38:682-92
Wend, Korinna; Wend, Peter; Drew, Brian G et al. (2013) ER? regulates lipid metabolism in bone through ATGL and perilipin. J Cell Biochem 114:1306-14
Wend, Peter; Runke, Stephanie; Wend, Korinna et al. (2013) WNT10B/?-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol Med 5:264-79
Garcia, Alejandro J; Tom, Colton; Guemes, Miriam et al. (2013) ER? signaling regulates MMP3 expression to induce FasL cleavage and osteoclast apoptosis. J Bone Miner Res 28:283-90
Calkins, Kara; Lowe, Allison; Shew, Stephen B et al. (2013) Short-term intravenous fish oil and pediatric intestinal failure associated liver disease: 3-year follow-up on liver function and nutrition. J Pediatr Surg 48:228-32
Bhattacharya, Debika; Lewis, Martha J; Lassmann, Britta et al. (2013) Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach. J Virol Methods 190:34-40

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