description): The primary goal this application for a Child Health Research Career Development Award is the training and development of pediatric scientists. To accomplish this goal, the junior pediatric faculty , recruited mostly from the pool of fellows and residents, will perform research under the guidance of established mentors. The activities of the junior investigators and their mentors will be supported by a) Administration that identifies, selects and monitors the progress of the young scientists and promotes the recruitment of women and minorities. b) Molecular and Cell Biologv Core Laboratories that provide space and equipment, as well as training in the selection and application of contemporary methodology to problems addressed by individual research projects. c) Basic Science Education Program that integrate principles of experimental design with the modem application of molecular biology, cell science and embryology, among others, to the solution of relevant pediatric problems. d) Clinical Investigation Education Program that provides formal instruction in the distinct conceptual, methodological and analytical skills that this separate discipline of clinical research requires. Having these complementary tracks will generate opportunities to bridge the gap between bench and bedside.
| Goodkin, Howard P; Joshi, Suchitra; Mtchedlishvili, Zakaria et al. (2008) Subunit-specific trafficking of GABA(A) receptors during status epilepticus. J Neurosci 28:2527-38 |
| Goodkin, Howard R; Joshi, Suchitra; Kozhemyakin, Maxim et al. (2007) Impact of receptor changes on treatment of status epilepticus. Epilepsia 48 Suppl 8:14-5 |
| Goodkin, Howard P; Sun, Chengsan; Yeh, Jwu-Lai et al. (2007) GABA(A) receptor internalization during seizures. Epilepsia 48 Suppl 5:109-13 |
| Gordon, Phillip V; Herman, Andrew C; Marcinkiewicz, Marek et al. (2007) A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. J Pediatr Gastroenterol Nutr 45:509-19 |
| Carver, D Jeannean; Gaston, Benjamin; Deronde, Kimberly et al. (2007) Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione. Am J Respir Cell Mol Biol 37:255-63 |
| Kiley, Susan C; Chevalier, Robert L (2007) Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF. Am J Physiol Renal Physiol 293:F895-903 |
| Buck, Marcia L; Gurka, Matthew J; Goodkin, Howard P (2007) Postmarketing modifications in the safety labeling of the new antiepileptics. Neurology 68:1536-7 |
| Zaman, Khalequz; Carraro, Silvia; Doherty, Joseph et al. (2006) S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. Mol Pharmacol 70:1435-42 |
| Gordon, Phillip V; Paxton, Jessica B; Kuemmerle, John F et al. (2005) A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells. Am J Physiol Gastrointest Liver Physiol 289:G79-87 |
| Goodkin, Howard P; Yeh, Jwu-Lai; Kapur, Jaideep (2005) Status epilepticus increases the intracellular accumulation of GABAA receptors. J Neurosci 25:5511-20 |
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