The Baylor WRHR Center Program will greatly enhance academic career development for the Ob/Gyn physician investigator pursuing molecular medicine. On behalf of Baylor College of Medicine (BCM) Department of Obstetrics and Gynecology and University of Texas (UT) M.D. Anderson Cancer Center (M.DAC.C) Department of Gynecologic Oncology, this WRHR proposal is submitted. Baylor/M.D. Anderson WRHR is ideally placed, with strong core resources at two leading institutions and an Advisory Committee from both institutions (Principal Investigator Joe Leigh Simpson, Program Director Colin Bishop; M.D. Anderson Primary Investigator David Gershenson; Baylor: Arthur Beaudet, Bert O'Malley, Martin Matzuk, Larry Chan, Huda Zoghbi, Dennis Bier, Baruch Brody; M.D. Anderson: Michele Pollen, Thomas Burke). Primary (Research) Mentors with world-class molecular programs have been identified using set criteria. Of the 22, 6 are in Ob/Gyn at Baylor, 3 in Gynecologic Oncology at M.D. Anderson, and 13 in other Baylor Departments. Most research mentors already collaborate actively with Baylor Ob/Gyn. Baylor and M.D. Anderson have a strong internal pool of Ob/Gyn candidates and proven ability to recruit outside K-12 Scholars, as judged by the highly successful Baylor BIRCWH Program. M.D. Anderson has the nation's largest Gynecologic Oncology Training Program, a four-year program that includes 2 years of laboratory research. Baylor/M.D. Anderson WRHR will also aggressively recruit candidates outside Baylor and M.D. Anderson, especially minority candidates. Selection steps include candidates visiting Baylor and M.D. Anderson, selecting a mentor and with the mentor, prepare a research and educational plan. Scholars will be selected by the Advisory Committee using defined criteria. Each educational plan will include not only developing laboratory investigative expertise under one of the 22 Research Mentors, but a) 5 required courses/seminars (Fundamentals of Clinical Investigation: Cellular and Molecular Biology of Disease: WRHR Molecular Medicine Seminar: WRHR/BIRCWH Seminars in Women's Health: Ethics Symposium), b) additional courses as needed, c) WRHR research conferences, at which Scholars have their work critiqued, d) yearly WRHR Distinguished Speaker, and e) once yearly meetings of all WRHR Scholars in the Southwest to leverage networking. Regularly scheduled evaluations assure sequential benchmarks of success: 1) peer review abstracts by early year -02, 2) publications in journals of defined impact factors, 3) year -03 RO3 or private foundation support, culminating in 4) RO1 submission and eventual support. A Secondary (Clinical/Academic) Mentor (e.g., Ob/Gyn Division Director) will provide WRHR Scholars clinical perspective and introduce them into leadership roles in their subspecialty. Missions of Baylor WRHR and Baylor BIRCWH are distinct. Fifth in NIH funding among medical schools and renowned for its genetic resources (faculty and facilities), Baylor with cooperation of M.D. Anderson is fully capable of training both BIRCWH and WRHR Scholars.
| Han, Sang Jun; Jung, Sung Yun; Wu, San-Pin et al. (2015) Estrogen Receptor ? Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell 163:960-74 |
| Pradeep, Sunila; Huang, Jie; Mora, Edna M et al. (2015) Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell 28:610-622 |
| Hawkins, Shannon M; Loomans, Holli A; Wan, Ying-Wooi et al. (2013) Expression and functional pathway analysis of nuclear receptor NR2F2 in ovarian cancer. J Clin Endocrinol Metab 98:E1152-62 |
| Shahzad, Mian M K; Shin, Yong-Hyun; Matsuo, Koji et al. (2013) Biological significance of HORMA domain containing protein 1 (HORMAD1) in epithelial ovarian carcinoma. Cancer Lett 330:123-9 |
| Han, Sang Jun; Hawkins, Shannon M; Begum, Khurshida et al. (2012) A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med 18:1102-11 |
| Hawkins, Shannon M; Andreu-Vieyra, Claudia V; Kim, Tae Hoon et al. (2012) Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer. Mol Endocrinol 26:1552-66 |
| Han, Hee Dong; Mora, Edna M; Roh, Ju Won et al. (2011) Chitosan hydrogel for localized gene silencing. Cancer Biol Ther 11:839-45 |
| Kim, Hye-Sun; Han, Hee Dong; Armaiz-Pena, Guillermo N et al. (2011) Functional roles of Src and Fgr in ovarian carcinoma. Clin Cancer Res 17:1713-21 |
| Hawkins, Shannon M; Buchold, Gregory M; Matzuk, Martin M (2011) Minireview: The roles of small RNA pathways in reproductive medicine. Mol Endocrinol 25:1257-79 |
| Hu, Wei; Lu, Chunhua; Dong, Han Hee et al. (2011) Biological roles of the Delta family Notch ligand Dll4 in tumor and endothelial cells in ovarian cancer. Cancer Res 71:6030-9 |
Showing the most recent 10 out of 30 publications
