Physicians who have completed a residency and perhaps a fellowship are usually superb clinicians, but generally are not well prepared to meet the research requirements of a career in academic medicine. This proposal describes a plan for a Male Reproductive Health Research (MRHR) program for internists, endocrinologists and/or urologists at the University of Washington. The major goal of this program is to provide the research training to enable young physicians to establish research careers as independent investigators. The principal training format proposed is a mentored experience with a successful investigator (clinical, translational or basic) for 2 to 5 years. During this time, the scholar (trainee) devotes most of his/her time to research projects, whereby he/she acquires the knowledge and skills to become independent and pursue a research intensive academic career. In addition, in the initial years of each scholar's research training, formal course work will be provided, as appropriate for the scholar's interests. This proposed MRHR program at the University of Washington has twelve mentors with extensive research experience and funding that collectively represent outstanding clinical, translational and basic science expertise in subject areas that directly relate to men's reproductive health. This is a multidisciplinary proposal in that the mentors have their primary expertise and appointments in the Departments of Medicine, Urology, Genome Sciences, Epidemiology, Pharmacology, Physiology and Biophysics and Obstetrics and Gynecology. Each proposed mentor has a record of excellence in research and documented experience in training young investigators. The Departments of Medicine and Urology will diligently recruit outside scholars, and, in addition, have a large internal pool of residents, fellows, and junior faculty members eager to compete for the scholar awards proposed here. The Medicine and Urology Departments and the School of Medicine at the University of Washington are prepared to make substantial commitments of resources and funding to support this proposed research program. The University of Washington is an ideal location for a career development program in male reproductive health. The University has a wealth of resources and experience in male reproductive research, and can provide many opportunities for scholars to embark on successful research careers, which will serve to foster new therapeutic breakthroughs in issues relevant to male reproductive health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD053984-05
Application #
7931936
Study Section
Special Emphasis Panel (ZHD1-DRG-D (05))
Program Officer
Moss, Stuart B
Project Start
2006-09-01
Project End
2012-08-14
Budget Start
2010-09-01
Budget End
2012-08-14
Support Year
5
Fiscal Year
2010
Total Cost
$394,075
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Berkseth, Kathryn E; Rubinow, Katya B; Melhorn, Susan J et al. (2018) Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men. Obesity (Silver Spring) 26:1898-1904
Rubinow, Katya B; Vaisar, Tomas; Chao, Jing H et al. (2018) Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men. J Clin Lipidol 12:1072-1082
Shnorhavorian, Margarett; Doody, David R; Chen, Vivien W et al. (2018) Knowledge of Clinical Trial Availability and Reasons for Nonparticipation Among Adolescent and Young Adult Cancer Patients: A Population-based Study. Am J Clin Oncol 41:581-587
Rubinow, Katya B; Chao, Jing H; Hagman, Derek et al. (2017) Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men. Am J Physiol Endocrinol Metab 313:E528-E539
Rubinow, Katya B; Rubinow, David R (2017) In immune defense: redefining the role of the immune system in chronic disease. Dialogues Clin Neurosci 19:19-26
Chao, Jing; Rubinow, Katya B; Kratz, Mario et al. (2016) Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men. J Clin Endocrinol Metab 101:3724-3731
Thirumalai, Arthi; Cooper, Lori A; Rubinow, Katya B et al. (2016) Stable Intraprostatic Dihydrotestosterone in Healthy Medically Castrate Men Treated With Exogenous Testosterone. J Clin Endocrinol Metab 101:2937-44
Shnorhavorian, Margarett; Harlan, Linda C; Smith, Ashley Wilder et al. (2015) Fertility preservation knowledge, counseling, and actions among adolescent and young adult patients with cancer: A population-based study. Cancer 121:3499-506
Rubinow, K B; Wang, S; den Hartigh, L J et al. (2015) Hematopoietic androgen receptor deficiency promotes visceral fat deposition in male mice without impairing glucose homeostasis. Andrology 3:787-96
Thirumalai, Arthi; Rubinow, Katya B; Page, Stephanie T (2015) An update on testosterone, HDL and cardiovascular risk in men. Clin Lipidol 10:251-258

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