This is a competitive renewal application for continued support of the Child Health Research Career Development Award (CHRCDA) Program in the Department of Pediatrics at the University of Texas Southwestern Medical Center (UTSW). UTSW and its Department of Pediatrics are ideally positioned to provide the supportive environment, the dedicated mentors, the critical core resources, and, most importantly, the stream of talented clinician-scientists that become the ultimate beneficiaries of this award. Our goal is to motivate and enable these young scientists to become the next generation of imaginative, independent, and sophisticated investigators focused on the diseases of major importance to infants and children throughout their lifetimes. We believe that our CHRCDA Program is uniquely qualified to accomplish this goal for the following reasons: 1) we have assembled a training faculty that offers enormous subject diversity, spanning nine university departments and four autonomous centers, and is at the same time uniformly focused on the developmental theme of our CHRCDA; 2) the biologic processes that we have identified for study are not only critically important to pediatrics, but also leverage existing strengths and well-established research and training collaborations between basic science and clinical departments at UT Southwestern; 3) recognizing that there has been no other time when the need to promote research careers among young physicians has been more crucial, our Department is committed to identifying the best candidates from an early stage and providing them with the encouragement and resources requisite to successful development into independent pediatric physician-scientists with a passion for discovery; and 4) despite its short course of four years, our Program has demonstrated its ability to achieve the goals established by NIH for the CHRCDA as evidenced by the success of all three of our graduating scholars in obtaining K08 or equivalent federal support either during their participation in the Program or within one year of their graduation. The CHRCDA Program at UT Southwestern will support a maximum of four Scholars at a time, each receiving an appointment of two years (which may be extended to three). During their participation in the Program, the Scholars will follow a personalized plan for research instruction and will dedicate a minimum of 80% of their effort to a rigorous research plan under the supervision of a mentor. Each Scholar's experience will continue to emphasize the identification of compelling clinically-relevant scientific questions, maintenance of project focus, creative experimental design, state-of-the-art technology, and thoughtful early career guidance.

Public Health Relevance

This is a competitive renewal application for continued support of the Child Health Research Career Development Award (CHRCDA) Program in the Department of Pediatrics at the University of Texas Southwestern Medical Center. The purpose of the Program is to provide rigorous research training to outstanding young pediatric physician-scientists seeking to better understand diseases of major importance to infants and children throughout their lifetimes.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
2K12HD068369-06
Application #
9053028
Study Section
Special Emphasis Panel (ZHD1-DSR-A (40))
Program Officer
Winer, Karen
Project Start
2010-12-05
Project End
2020-11-30
Budget Start
2016-02-09
Budget End
2016-11-30
Support Year
6
Fiscal Year
2016
Total Cost
$357,642
Indirect Cost
$26,492
Name
University of Texas Sw Medical Center Dallas
Department
Pediatrics
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Zhu, Wenhan; Winter, Maria G; Byndloss, Mariana X et al. (2018) Precision editing of the gut microbiota ameliorates colitis. Nature 553:208-211
Huo, Xiaofang; Zhang, Xi; Yu, Chunhua et al. (2018) Aspirin prevents NF-?B activation and CDX2 expression stimulated by acid and bile salts in oesophageal squamous cells of patients with Barrett's oesophagus. Gut 67:606-615
Starokadomskyy, P; Sifuentes-Dominguez, L; Gemelli, T et al. (2017) Evolution of the skin manifestations of X-linked pigmentary reticulate disorder. Br J Dermatol 177:e200-e201
Huo, Xiaofang; Agoston, Agoston T; Dunbar, Kerry B et al. (2017) Hypoxia-inducible factor-2? plays a role in mediating oesophagitis in GORD. Gut 66:1542-1554
Asanuma, Kiyotaka; Huo, Xiaofang; Agoston, Agoston et al. (2016) In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression. Gut 65:1416-26
Potera, Renee M; Jensen, Melissa J; Hilkin, Brieanna M et al. (2016) Neutrophil azurophilic granule exocytosis is primed by TNF-? and partially regulated by NADPH oxidase. Innate Immun 22:635-646
Sifuentes-Dominguez, Luis; Patel, Ashish S (2016) Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future. F1000Res 5:
Cheng, Edaire; Zhang, Xi; Wilson, Kathleen S et al. (2016) JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE. PLoS One 11:e0157376
Nadatani, Yuji; Huo, Xiaofang; Zhang, Xi et al. (2016) NOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett's Epithelial Cells. Cell Mol Gastroenterol Hepatol 2:439-453
Song, Jeongmin; Wilhelm, Cara L; Wangdi, Tamding et al. (2016) Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Cell 164:827-8

Showing the most recent 10 out of 26 publications