Abstract

We propose a K12 training program in genetics/genomics of lung disease for the Washington DC area. The proposed K12 will be integrated into the recently created Washington Institute of Clinical Translational Science, a consortium of Washington DC area academic medical centers. The Program will draw upon NIH funded lung and sleep researchers from four institutions: Children's National Medical Center, Howard University (a historically black university), Georgetown University, and George Washington University. The administration of the Program and laboratory training in genetics/genomics will be centered in the Research Center for Genetic Medicine in Children's National Medical Center. The Center is well-recognized for training, research, and technological innovations in genetics/genomics. Dr. Eric Hoffman serves as both the Director of the Research Center for Genetic Medicine and as Program Director for the proposed K12 genetics/genomics of lung training program. Formal Core Courses in genetics, genomics and proteomics will be taught at CNMC, GWU, and GU. The Didactic Research Curriculum will utilize the educational programs that have been developed to support K awards at CNMC and the other three participating institutions. Potential trainees will be drawn from all four participating institutions and aligned with mentors and projects that best match their interests and career trajectory. Research strengths of the proposed K12 lead and secondary mentors focus on asthma, lung remodeling, acute lung injury, sleep disorders, pediatric lung health, and health disparities in lung disease, as well as on genetics, genomics and proteomics. Technical strengths in genetics/genomics that will be used in research projects include single nucleotide polymorphism (SNP) association studies, mRNA and proteomic profiling, and bioinformatics. We propose to train three Basic and/or Clinical Translational Fellows per year, for a total of 6-8 trainees graduating from the rigorous program over the proposed 5 yr period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HL090020-04
Application #
7905161
Study Section
Special Emphasis Panel (ZHL1-CSR-A (S1))
Program Officer
Colombini-Hatch, Sandra
Project Start
2007-09-27
Project End
2013-07-31
Budget Start
2010-08-01
Budget End
2012-07-31
Support Year
4
Fiscal Year
2010
Total Cost
$399,600
Indirect Cost

  Institution

Name
Children's Research Institute
Department
Type
DUNS #
143983562
City
Washington
State
DC
Country
United States
Zip Code
20010

  Publications

Rodriguez-Martinez, Carlos E; Sossa-Briceño, Monica P; Nino, Gustavo (2018) Systematic review of instruments aimed at evaluating the severity of bronchiolitis. Paediatr Respir Rev 25:43-57
Nino, Cesar L; Perez, Geovanny F; Isaza, Natalia et al. (2018) Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Sci Rep 8:5526
Megalaa, Rosemary; Perez, Geovanny F; Kilaikode-Cheruveettara, Sasikumar et al. (2018) Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification. J Investig Med 66:46-51
Rodríguez-Martínez, Carlos E; Sossa-Briceño, Monica P; Nino, Gustavo (2017) A systematic review of instruments aimed at evaluating metered-dose inhaler administration technique in children. J Asthma 54:173-185
Perez, Geovanny F; Pérez-Losada, Marcos; Isaza, Natalia et al. (2017) Nasopharyngeal microbiome in premature infants and stability during rhinovirus infection. J Investig Med 65:984-990
Nino, Gustavo; Govindan, R B; Al-Shargabi, Tareq et al. (2016) Premature Infants Rehospitalized because of an Apparent Life-Threatening Event Had Distinctive Autonomic Developmental Trajectories. Am J Respir Crit Care Med 194:379-81
Pancham, Krishna; Sami, Iman; Perez, Geovanny F et al. (2016) Human Metapneumovirus Infection is Associated with Severe Respiratory Disease in Preschool Children with History of Prematurity. Pediatr Neonatol 57:27-34
Aragona, Elena; El-Magbri, Eussra; Wang, Justin et al. (2016) Impact of Obesity on Clinical Outcomes in Urban Children Hospitalized for Status Asthmaticus. Hosp Pediatr 6:211-8
Peters-Hall, Jennifer R; Brown, Kristy J; Pillai, Dinesh K et al. (2015) Quantitative proteomics reveals an altered cystic fibrosis in vitro bronchial epithelial secretome. Am J Respir Cell Mol Biol 53:22-32
Perez, Geovanny F; Rodriguez-Martinez, Carlos E; Nino, Gustavo (2015) Rhinovirus-Induced Airway Disease: A Model to Understand the Antiviral and Th2 Epithelial Immune Dysregulation in Childhood Asthma. J Investig Med 63:792-5

Showing the most recent 10 out of 39 publications