This proposal to develop Pediatric Neurology residents into independent investigators at the Albert Einstein College of Medicine (AECOM) is based on a coordinated program of mentoring, didactic course work, collegial interdisciplinary collaboration and research support. The AECOM Pediatric Neurology faculty has achieved world-wide recognition in epilepsy, audition and language processing and autism research. The overall goal is to train qualified Pediatric Neurology in investigating the impact of epilepsy on brain development, language and behavior as a basis for an academic career. We already have identified three candidate trainees. Each will be paired with accomplished and dedicated Mentors. There is a Phase I didactic component through a K30 funded curriculum for clinical researchers and courses of the Sue Golding Graduate Division. Individualized courses of instruction will be determined for each Trainee. A committee focusing on mentoring and research collaboration will track the progress of each Trainee. The Leadership of the program includes 1) the Executive Committee overseeing the entire program and consisting of the PI, Dr. S. L. Moshe, Director of Pediatric Neurology and Clinical Neurophysiology, and Drs. S. Shinnar, Director of the Epilepsy Center, P. Marantz, Director of AECOM's K30 program, and co-leader of the Mentored Clinical Research Scholar Program and Dr. A. M. Etgen, the previous Director of the Sue Golding Graduate Division and 2) an Internal Advisory Committee composed of leaders of AECOM's neuroscience research. There is a strong foundation in NIH supported investigations, and the program will be integrated with other basic and clinical programs. Under the aegis of Dean D. Purpura, the Institution is committed to train and mentor young investigators in research. AECOM's network of clinical affiliates provides high quality care to a large, population. Its epicenter is the Bronx, a county with over 1.3 million residents, of whom, over 80% are members of ethnic/racial traditionally underserved minorities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12NS048856-02
Application #
6935841
Study Section
NST-2 Subcommittee (NST)
Program Officer
Hirtz, Deborah G
Project Start
2004-08-15
Project End
2009-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$387,302
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Neurology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Nordli Jr, Douglas R; Moshe, Solomon L; Shinnar, Shlomo et al. (2012) Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study. Neurology 79:2180-6
Moshé, Solomon L; Perucca, Emilio; Wiebe, Samuel et al. (2011) The International League Against Epilepsy at the threshold of its second century: year 1. Epilepsia 52:185-7
Hasson, Henry; Malhotra, Samit; Giorgi, Filippo S et al. (2010) Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus. Neurol Sci 31:103-5
Sogawa, Yoshimi; Masur, David; O'Dell, Christine et al. (2010) Cognitive outcomes in children who present with a first unprovoked seizure. Epilepsia 51:2432-9
Fishman, Olga; Sogawa, Yoshimi; Moshe, S L (2010) Transient axial hypotonia and alteration of consciousness in an infant with Chiari I malformation. Semin Pediatr Neurol 17:17-23
Coppola, Antonietta; Moshé, Solomon L (2009) Why is the developing brain more susceptible to status epilepticus? Epilepsia 50 Suppl 12:25-6
Hasson, Henry; Kim, Mimi; Moshe, Solomon L (2008) Effective treatments of prolonged status epilepticus in developing rats. Epilepsy Behav 13:62-9
Valicenti-McDermott, Maria D; McVicar, Kathryn; Cohen, Herbert J et al. (2008) Gastrointestinal symptoms in children with an autism spectrum disorder and language regression. Pediatr Neurol 39:392-8
Scantlebury, Morris H; Heida, James G; Hasson, Henry J et al. (2007) Age-dependent consequences of status epilepticus: animal models. Epilepsia 48 Suppl 2:75-82
Valicenti-McDermott, Maria; McVicar, Kathryn; Rapin, Isabelle et al. (2006) Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. J Dev Behav Pediatr 27:S128-36

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