: This is a proposal to implement a rigorous and highly structured mentored clinical scholar program in patient-oriented research that is broad, cross disciplinary and focused on the area of clinical pharmacology and experimental therapeutics. This key field bridges molecular medicine and health care and covers all areas of clinical medicine. We will place a strong emphasis on the conduction of research in special populations such as women, children, and members of ethnic minority groups. We will likewise emphasize the recruitment, retention, and training of scholars who are members of under represented groups. This application is being jointly submitted by UCLA, a top 10 university, and by Drew University, one of four historically Black medical colleges, and the only one west of the Mississippi. These two institutions have a history of highly productive collaborations. The General Clinical Research Centers (GCRCs) from both institutions will be key resources for the program. We have a large and superbly qualified pool of identified lead mentors. Scholars will also work closely with our Data Coordinating Center and Data Management Safety Centers. The P.I., Dr. Julio Licinio, is an accomplished Hispanic patient-oriented investigator. This mentored scholar program will be guided by an Advisory Committee that includes highly accomplished patient orient investigators, academic leaders, and one basic scientist, Dr. Louis Ignarro, a Nobel Laureate. We have also appointed an External Advisory Board that includes experts in academic medicine and communication of science. In addition to our research and training emphasis on minorities and special populations, we have a highly innovative and comprehensive program of instruction on the communication of science. We will use existing structures, such as the UCLA Graduate Training Program in Translational Investigation (K30) and the Master's Program in Clinical Research, and will also develop novel didactic components that are described in this application. Each scholar will have, in addition to her/his lead mentor, a co-lead mentor with expertise in clinical research design and statistics, and a research preceptor who is not directly involved in their project to provide additional mentorship. Scholars will work closely with the Advisory Committee. UCLA has provided substantial institutional academic and financial support to this program. Our goal is to rapidly become the leading mentored scholar program in this area and to become a national resource for patient-oriented investigation that is focused on special populations, including ethnic minorities. Educators from the UCLA Center for Educational Development and Research in the School of Medicine will implement mechanisms to evaluate the quality and outcomes of the program for purposes of continuous improvement.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12RR017611-04
Application #
6932321
Study Section
Special Emphasis Panel (ZRR1-CR-7 (01))
Program Officer
Wilde, David B
Project Start
2002-09-30
Project End
2007-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
4
Fiscal Year
2005
Total Cost
$1,285,300
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Paz-Filho, Gilberto; Mastronardi, Claudio A; Licinio, Julio (2015) Leptin treatment: facts and expectations. Metabolism 64:146-56
Licinio, J; Negrao, A B; Wong, M-L (2014) Plasma leptin concentrations are highly correlated to emotional states throughout the day. Transl Psychiatry 4:e475
Wong, M-L; Dong, C; Andreev, V et al. (2012) Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. Mol Psychiatry 17:624-33
Paz-Filho, G J; Andrews, D; Esposito, K et al. (2009) Effects of leptin replacement on risk factors for cardiovascular disease in genetically leptin-deficient subjects. Horm Metab Res 41:164-7
Andreev, V P; Paz-Filho, G; Wong, M-L et al. (2009) Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment. Horm Metab Res 41:142-51
Riedl, Marc A; Saxon, Andrew; Diaz-Sanchez, David (2009) Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol 130:244-51
Paz-Filho, Gilberto; Esposito, Karin; Hurwitz, Barry et al. (2008) Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients. Am J Physiol Endocrinol Metab 295:E1401-8
Paz-Filho, G J; Ayala, A; Esposito, K et al. (2008) Effects of leptin on lipid metabolism. Horm Metab Res 40:572-4
Mastronardi, Claudio; Whelan, Fiona; Yildiz, Ozlem A et al. (2007) Caspase 1 deficiency reduces inflammation-induced brain transcription. Proc Natl Acad Sci U S A 104:7205-10
Wong, Ma-Li; Whelan, Fiona; Deloukas, Panagiotis et al. (2006) Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc Natl Acad Sci U S A 103:15124-9

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