Dramatic increases in the knowledge of basic disease mechanisms from the laboratory are slow to find the bedside, clinic or general population. These delays are due,in part, to a lack of enough well-trained clinical researchers to translate scientific discoveries in human populations. Recognizing this deficit, the University of Minnesota and its Academic Health Center (AHC) developed a strategic plan in 2003 prioritizing clinical research (CR) at all University levels from undergraduates to the senior faculty. The proposed K12 program fits well into those plans and will enhance the substantial Minnesota CR investment. This K12 proposal embraces the spectrum of CR from observational epidemiology to clinical trials to outcomes research. Recognizing the multidisciplinary nature of CR, we include the Schools of Dentistry, Medicine, Nursing, Pharmacy and Public Health in CR scholar identification, training and development. These disciplines have a history of working together to provide leadership for CR. Beginning with clinical specialty fellows, postdoctoral students and junior faculty, we will select CR scholars to participate in current and new coursework from an ongoing K30 grant. Advised by three-person multidisciplinary mentor teams, including a biostatistician, the scholars will access substantial resources and infrastructure in the AHC including: 1) Skilled, experienced and enthusiastic senior mentors; 2) Biostatisticians with an international reputation for CR; 3) A General Clinical Research Center (GCRC) with a 25-year record of productivity; 4) A pharmaceutical center; 5) Veterans Administration and Hennepin County hospitals with diverse populations; 6) A minority recruitment program; 7) A substantial portfolio of federal and industry funded CR projects,and; 8) A proposed Shared Clinical Research Support Group. There is a history of collaboration among AHC schools in multidisciplinary CR using a team approach. This proposal expands on a successful CR enterprise in an institution with a ten-year strategic investment plan. The goal is to improve health and cure diseases through CR. This proposal merges many University of Minnesota strengths in a systematic, focused career development training program for NIH CR scholars.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12RR023247-04
Application #
7493462
Study Section
Special Emphasis Panel (ZHD1-MRG-C (16))
Program Officer
Merchant, Carol
Project Start
2005-09-23
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
4
Fiscal Year
2008
Total Cost
$3,639,600
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Yu, Fang; Vock, David M; Barclay, Terry R (2018) Executive function: Responses to aerobic exercise in Alzheimer's disease. Geriatr Nurs 39:219-224
Moana-Filho, Estephan J; Alonso, Aurelio A; Kapos, Flavia P et al. (2017) Multifactorial assessment of measurement errors affecting intraoral quantitative sensory testing reliability. Scand J Pain 16:93-98
Nixdorf, Donald R; Law, Alan S; Lindquist, Kimberly et al. (2016) Frequency, impact, and predictors of persistent pain after root canal treatment: a national dental PBRN study. Pain 157:159-65
Pigg, Maria; Nixdorf, Donald R; Nguyen, Ruby H N et al. (2016) Validity of Preoperative Clinical Findings to Identify Dental Pulp Status: A National Dental Practice-Based Research Network Study. J Endod 42:935-42
Yu, Fang; Demorest, Shanda L; Vock, David M (2015) Testing a modified perceived exertion scale for Alzheimer's disease. Psych J 4:38-46
Bosch, Tyler A; Dengel, Donald R; Ryder, Justin R et al. (2015) Fitness Level is Associated with Sex-Specific Regional Fat Differences in Normal Weight Young Adults. J Endocrinol Diabetes 2:
Shapiro, Elsa G; Nestrasil, Igor; Rudser, Kyle et al. (2015) Neurocognition across the spectrum of mucopolysaccharidosis type I: Age, severity, and treatment. Mol Genet Metab 116:61-8
Moana-Filho, Estephan J; Bereiter, David A; Nixdorf, Donald R (2015) Amplified Brain Processing of Dentoalveolar Pressure Stimulus in Persistent Dentoalveolar Pain Disorder Patients. J Oral Facial Pain Headache 29:349-62
Law, A S; Nixdorf, D R; Aguirre, A M et al. (2015) Predicting severe pain after root canal therapy in the National Dental PBRN. J Dent Res 94:37S-43S
Nixdorf, Donald R; Law, Alan S; John, Mike T et al. (2015) Differential diagnoses for persistent pain after root canal treatment: a study in the National Dental Practice-based Research Network. J Endod 41:457-63

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