The broad objective of this proposal is to identify mechanisms of hematopoietic stem cell damage occurring after cancer chemotherapy use. We intend to determine if this damage is lessened (or exacerbated) by use of cytokines with chemotherapy and to discover ways to avoid such damage. Changes in primitive hematopoietic stem cell (PHSC) function and numbers will be assessed. Changes in PHSC cycling will also be examined to determine if such changes are, in part, accountable for increased PHSC vulnerability after chemotherapy and subsequent PHSC exhaustion of dysfunction. The hypothesis that chemotherapy alters normal physiologic growth responsiveness will also be tested.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Minority School Faculty Development Awards (K14)
Project #
5K14HL003148-05
Application #
6017186
Study Section
Special Emphasis Panel (ZHL1-CCT-L (F1))
Project Start
1995-06-01
Project End
2000-11-30
Budget Start
1999-06-01
Budget End
2000-11-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Pediatrics
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Player, R; Richards Jr, J M; Kohler, C L et al. (1994) Scale for assessing functional impairment in adults with asthma. J Asthma 31:437-44