Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Minority School Faculty Development Awards (K14)
Project #
5K14HL003373-02
Application #
2211614
Study Section
Special Emphasis Panel (ZHL1-CCT-L (F1))
Project Start
1995-05-01
Project End
1996-06-30
Budget Start
1996-05-01
Budget End
1996-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Genetics
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Peluffo, R D; Arguello, J M; Lingrel, J B et al. (2000) Electrogenic sodium-sodium exchange carried out by Na,K-ATPase containing the amino acid substitution Glu779Ala. J Gen Physiol 116:61-73
Shi, H G; Mikhaylova, L; Zichittella, A E et al. (2000) Functional role of cysteine residues in the (Na,K)-ATPase alpha subunit. Biochim Biophys Acta 1464:177-87
Zichittella, A E; Shi, H G; Arguello, J M (2000) Reactivity of cysteines in the transmembrane region of the Na, K-ATPase alpha subunit probed with Hg(2+). J Membr Biol 177:187-97
Peluffo, R D; Arguello, J M; Berlin, J R (2000) The role of Na,K-ATPase alpha subunit serine 775 and glutamate 779 in determining the extracellular K+ and membrane potential-dependent properties of the Na,K-pump. J Gen Physiol 116:47-59
Arguello, J M; Whitis, J; Cheung, M C et al. (1999) Functional role of oxygen-containing residues in the fifth transmembrane segment of the Na,K-ATPase alpha subunit. Arch Biochem Biophys 364:254-63
Lingrel, J B; Arguello, J M; Van Huysse, J et al. (1997) Cation and cardiac glycoside binding sites of the Na,K-ATPase. Ann N Y Acad Sci 834:194-206
Kuntzweiler, T A; Arguello, J M; Lingrel, J B (1996) Asp804 and Asp808 in the transmembrane domain of the Na,K-ATPase alpha subunit are cation coordinating residues. J Biol Chem 271:29682-7
Arguello, J M; Peluffo, R D; Feng, J et al. (1996) Substitution of glutamic 779 with alanine in the Na,K-ATPase alpha subunit removes voltage dependence of ion transport. J Biol Chem 271:24610-6
Palasis, M; Kuntzweiler, T A; Arguello, J M et al. (1996) Ouabain interactions with the H5-H6 hairpin of the Na,K-ATPase reveal a possible inhibition mechanism via the cation binding domain. J Biol Chem 271:14176-82