Platelets and Leukocyte Phosphodiesterase

Omburo, George A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Minority School Faculty Development Awards (K14)
• Project #: 5K14HL003375-02
• Application #: 2211619
• Study Section: Special Emphasis Panel (ZHL1-CCT-L (F1))
• Project Start: 1995-04-01
• Project End: 2000-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Temple University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19122

Publications

Omburo, G A; Jacobitz, S; Torphy, T J et al. (1998) Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A. Cell Signal 10:491-7

Zhu, W H; Majluf-Cruz, A; Omburo, G A (1998) Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism. Life Sci 63:265-74

Omburo, G A; Torphy, T J; Scott, G et al. (1997) Inactivation of recombinant monocyte cAMP-specific phosphodiesterase by cAMP analog, 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic monophosphate. Blood 89:1019-26

Ghazaleh, F A; Omburo, G A; Colman, R W (1996) Evidence for the presence of essential histidine and cysteine residues in platelet cGMP-inhibited phosphodiesterase. Biochem J 317 ( Pt 2):495-501