We propose to conduct a prospective cohort study of preventable risk factors for asthma among participants in the Nurses' Health Study II (116,678 female nurses, aged 25-42 in 1989). We will begin by examining the dietary hypo-theses that high intake of antioxidants (e.g., vitamin C, vitamin E, and B-carotene), magnesium, potassium and n-3 polyunsaturated fatty acids decreases risk of asthma, whereas high intake of sodium and specific fatty acids (e.g., linoleic acid) increases risk. Dietary factors were measured in 1991 using a semiquantitative food frequency questionnaire that has been extensively validated. Incident cases of asthma will be identified by mailed question-naire, and then confirmed using a supplementary questionnaire and selective review of medical records. During four years of follow-up (1991-1995), we expect approximately 1,500 cases of confirmed incident asthma; this will provide a power of over 99 percent to detect a trend across quintiles of dietary intake. The rising incidence of asthma and its high societal cost make asthma prevention an important public health goal. We believe that this study, which is very cost effective since it makes use of an existing cohort, will provide information which could have direct clinical application to reduce risk of asthma.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Minority School Faculty Development Awards (K14)
Project #
5K14HL003533-05
Application #
6182614
Study Section
Special Emphasis Panel (ZHL1-CSR-K (F1))
Project Start
1996-08-01
Project End
2001-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
5
Fiscal Year
2000
Total Cost
$122,501
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Corliss, Heather L; Rosario, Margaret; Wypij, David et al. (2008) Sexual orientation disparities in longitudinal alcohol use patterns among adolescents: findings from the Growing Up Today Study. Arch Pediatr Adolesc Med 162:1071-8
Mukamal, Kenneth J; Kawachi, Ichiro; Miller, Matthew et al. (2007) Drinking frequency and quantity and risk of suicide among men. Soc Psychiatry Psychiatr Epidemiol 42:153-60
Ziyadeh, Najat J; Prokop, Lisa A; Fisher, Laurie B et al. (2007) Sexual orientation, gender, and alcohol use in a cohort study of U.S. adolescent girls and boys. Drug Alcohol Depend 87:119-30
Mukamal, Kenneth J; Chiuve, Stephanie E; Rimm, Eric B (2006) Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles. Arch Intern Med 166:2145-50
Austin, S Bryn; Ziyadeh, Najat; Fisher, Laurie B et al. (2004) Sexual orientation and tobacco use in a cohort study of US adolescent girls and boys. Arch Pediatr Adolesc Med 158:317-22
Kahn, Jessica A; Huang, Bin; Austin, S Bryn et al. (2004) Development of a scale to measure adolescents' beliefs and attitudes about postponing sexual initiation. J Adolesc Health 35:425.e1-10
Radeos, Michael S; Camargo Jr, Carlos A (2004) Predicted peak expiratory flow: differences across formulae in the literature. Am J Emerg Med 22:516-21
Santillan, Alfredo A; Camargo Jr, Carlos A; Ramirez-Rivera, Alicia et al. (2003) Association between beta2-adrenoceptor polymorphisms and asthma diagnosis among Mexican adults. J Allergy Clin Immunol 112:1095-100
Silverman, Robert A; Boudreaux, Edwin D; Woodruff, Prescott G et al. (2003) Cigarette smoking among asthmatic adults presenting to 64 emergency departments. Chest 123:1472-9
Keahey, Laine; Bulloch, Blake; Becker, Allan B et al. (2002) Initial oxygen saturation as a predictor of admission in children presenting to the emergency department with acute asthma. Ann Emerg Med 40:300-7

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