If functional abnormalities are detected, human genetic studies will be done to determine if the abnormality is inheritable and/or molecular biology techniques will be used to specifically identify the abnormality. Using this approach, it can be determined if a genetic discriminant or variation is genetically involved in the psychiatric illness. The applicants initial research project will focus on evaluating the content and functioning of G proteins in the peripheral blood cells of patients with primary mood disorders, and the effects of lithium on these measures. Receptor binding studies and G protein activation of the enzymes adenylate cyclase and phospholipase C, will be used to assess the functional activity of the G proteins.Quantitation of the subtypes of G proteins will be done by ELISA using commercially available antibodies. If a discriminant variable is detected in the probands, human genetic studies and/or molecular biology assessments will be done.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Unknown (K20)
Project #
1K20MH000870-01A1
Application #
3088871
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1991-03-01
Project End
1996-06-30
Budget Start
1991-03-01
Budget End
1992-06-30
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Emory University
Department
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322