The research program elaborates upon a PET study recently conducted in Arizona by Dr. Lane and colleagues in which happiness, sadness and disgust were successfully induced in normal women in the PET laboratory. Subjects were carefully selected to maximize the likelihood that they would have intense experiences and could describe their experiences accurately. The analysis of cerebral blood flow (BF) data, a marker of local neuronal activity, is currently being completed. To prepare for the two major PET studies supported by this grant, three psychometric studies will aim to enhance the effectiveness of the film and imagery stimuli for unselected subjects in a manner specifically suited for PET utilizing the radiotracer 15O-water. A psychophysiological study (N=200) will then determine whether the variance in the autonomic response to emotion-evoking stimuli explained by self-report varies as a function of individual differences in the style of emotion self-regulation. Two PET studies involving absolute quantitation of BF using the radiotracer 15O- water will then follow (Total N=40). The goals of these two studies are to identify the functional neuroanatomy of happiness, sadness, disgust, anger and fear in normal women and to determine whether sex differences exist in BF patterns during anger, fear and happiness. Another goal is to compare two groups differing in their style of emotion self-regulation if supported by the psychophysiological data, or to compare that of right and left- handers if not.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Unknown (K20)
Project #
5K20MH000972-04
Application #
2415742
Study Section
Emotion and Personality Review Committee (EMP)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Arizona
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Lane, R D; Sechrest, L; Riedel, R et al. (2000) Pervasive emotion recognition deficit common to alexithymia and the repressive coping style. Psychosom Med 62:492-501
Lane, R D; Chua, P M; Dolan, R J (1999) Common effects of emotional valence, arousal and attention on neural activation during visual processing of pictures. Neuropsychologia 37:989-97
Lane, R D; Reiman, E M; Axelrod, B et al. (1998) Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. J Cogn Neurosci 10:525-35
Lane, R D; Sechrest, L; Riedel, R (1998) Sociodemographic correlates of alexithymia. Compr Psychiatry 39:377-85
Reiman, E M; Lane, R D; Ahern, G L et al. (1997) Neuroanatomical correlates of externally and internally generated human emotion. Am J Psychiatry 154:918-25
Lane, R D; Ahern, G L; Schwartz, G E et al. (1997) Is alexithymia the emotional equivalent of blindsight? Biol Psychiatry 42:834-44
Lane, R D; Fink, G R; Chau, P M et al. (1997) Neural activation during selective attention to subjective emotional responses. Neuroreport 8:3969-72
Lane, R D; Reiman, E M; Ahern, G L et al. (1997) Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry 154:926-33
Lane, R D; Reiman, E M; Bradley, M M et al. (1997) Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia 35:1437-44
Lane, R D; Sechrest, L; Reidel, R et al. (1996) Impaired verbal and nonverbal emotion recognition in alexithymia. Psychosom Med 58:203-10

Showing the most recent 10 out of 11 publications