The DNA of eukaryotic organisms is pacl The scientific goal of this grant is to gain a better understanding of the mechanisms responsible for regulating the structure of chromatin and to furthermore explore how this regulation is involved in development. This research will lead to a greater understanding of developmental processes in general, with specific applications to hematopoietic development. Relevance These studies will further elucidate how components responsible for packaging the genome into the nucleus interact with other proteins to regulate gene expression. These insights will shed further light on gene regulation and developmental processes in general.Public Health Relevance