The overall goal of this proposal is to provide the mentoring, coursework, and research experience to allow the applicant to develop into an independent investigator performing behavioral interventions in HIV+ women with co-occurring alcohol use and depression/or anxiety disorders. Alcohol, depression, and anxiety independently affect HIV disease progression. Importantly, alcohol use frequently co-occurs with depression and anxiety, particularly among women. Despite the relative frequency of co-occurrence, the impact of co-occurring alcohol use and depression/anxiety has not been evaluated among HIV+ women. The goals of this research proposal are three-fold: 1) to examine the effect of co-occurring alcohol and depression on HIV disease progression (HIV-RNA, adherence, quality of life, mortality) in HIV+ women; 2) to examine the effect of co-occurring alcohol and anxiety on HIV disease progression in HIV+ women 3) to obtain preliminary data of the effectiveness of brief alcohol interventions in HIV+ women with co-occurring disorders. Specific goals will be accomplished by building upon 2 unique resources for clinical research: a recently funded RCT of brief alcohol interventions, and the Johns Hopkins HIV Clinical Cohort, The applicant will add psychological and quality of life measures which will enable her to assess 1) the impact of co-occurring disorders on HIV related disease outcomes both cross-sectionally and longitudinally, 2) brief alcohol intervention effectiveness among women with co-occurring disorders. In addition, enhanced psychological assessment will allow the applicant to examine the role of subthreshold psychiatric symptoms in alcohol use and HIV disease progression, which have not been explored within the contexts of alcohol use or HIV disease. The skills necessary to accomplish the above goals will be obtained through 1) mentorship by experts in alcohol use disorders, HIV epidemiology and mental health 2) directed readings and seminars arid 3) coursework in mental health epidemiology, alcohol and drug use disorders, and the design and analysis of clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23AA015313-04
Application #
7407554
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Roach, Deidra
Project Start
2005-05-16
Project End
2010-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
4
Fiscal Year
2008
Total Cost
$178,926
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Yang, Cui; DeBartolo, Peter; McCaul, Mary E et al. (2018) The role of personal and household members' substance use in health-related quality of life in women living with HIV/AIDS. AIDS Care 30:473-479
Barai, Nikita; Monroe, Anne; Lesko, Catherine et al. (2017) The Association Between Changes in Alcohol Use and Changes in Antiretroviral Therapy Adherence and Viral Suppression Among Women Living with HIV. AIDS Behav 21:1836-1845
Hutton, Heidi; Lesko, Catherine R; Chander, Geetanjali et al. (2017) Differential effects of perceived stress on alcohol consumption in moderate versus heavy drinking HIV-infected women. Drug Alcohol Depend 178:380-385
Sam, Tanyka Suzanne; Hutton, Heidi E; Lau, Bryan et al. (2015) Antiretroviral Therapy Use, Medication Adherence, and Viral Suppression Among PLWHA with Panic Symptoms. AIDS Behav 19:2049-56
Lewis, Dinah; Hutton, Heidi E; Agee, Tracy A et al. (2015) Alcohol Use and Unintended Sexual Consequences among Women Attending an Urban Sexually Transmitted Infections Clinic. Womens Health Issues 25:450-7
Chander, Geetanjali; Hutton, Heidi E; Lau, Bryan et al. (2015) Brief Intervention Decreases Drinking Frequency in HIV-Infected, Heavy Drinking Women: Results of a Randomized Controlled Trial. J Acquir Immune Defic Syndr 70:137-45
Chander, Geetanjali; Zhang, YiYi; dosReis, Susan et al. (2012) Is serious mental illness associated with earlier death among persons with HIV? Ten year follow up in Maryland Medicaid Recipients. J AIDS HIV Res 4:213-218
Illangasekare, Samantha; Tello, Monique; Hutton, Heidi et al. (2012) Clinical and mental health correlates and risk factors for intimate partner violence among HIV-positive women in an inner-city HIV clinic. Womens Health Issues 22:e563-9
Kowalski, Stefan; Colantuoni, Elizabeth; Lau, Bryan et al. (2012) Alcohol consumption and CD4 T-cell count response among persons initiating antiretroviral therapy. J Acquir Immune Defic Syndr 61:455-61
Chander, Geetanjali; Stanton, Cassandra; Hutton, Heidi E et al. (2012) Are smokers with HIV using information and communication technology? Implications for behavioral interventions. AIDS Behav 16:383-8

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