The long-term objective of this Mentored Patient-Oriented Research Career Development Award is to develop the Principle Investigator's skills and knowledge in observational study design, scale development and validation and outcome studies focused on psychoactive drug use and its impact on outcomes in critically ill patients. The thrust of this research project is three-fold: 1) To determine the association of psychoactive (sedative-hypnotic, narcotic and anticholinergic) drugs with persistent delirium post-ICU discharge. Persistent delirium is defined as delirium, which is present in the ICU and is also present post-ICU discharge. We will examine the drugs individually and in combinations, examine the influence of drug class and examine the influence of cumulative dose of drug received. 2) To identify leading drugs or combinations (called HIGH RISK DRUGS) associated with the highest risk of persistent delirium. 3) Controlling for other delirium risk factors (e.g., dementia, illness severity, invasive procedures, medical comorbidities, invasive procedures, and metabolic abnormalities) we will determine the independent contribution of the HIGH RISK DRUGS to persistent delirium. The applicant will achieve the long-term objectives by completing the well-integrated specific aims under the supervision of a highly qualified mentor and guidance by an Advisory Committee with multidisciplinary ICU clinical research expertise, experience in delirium research, and assistance by expert consultants in clinical epidemiology and biostatistics. The applicant has a focused program of didactic courses, participation in research seminars and training in pharmacology that will complement her previous MPH curriculum. The research projects have been selected, in part because they will provide an excellent training vehicle for furthering the applicant's transition to an independent investigator in ICU patient-oriented research. Ultimately, we hope this work will lead to the development of specific interventions in ICU drug therapy vital to the care of more than four million critically ill patients in the United States.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23AG023023-01A1
Application #
6819133
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wagster, Molly V
Project Start
2004-09-15
Project End
2009-06-30
Budget Start
2004-09-15
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$130,275
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Chima-Melton, Chidinma; Murphy, Terrence E; Araujo, Katy L B et al. (2016) The Impact of Race on Intensity of Care Provided to Older Adults in the Medical Intensive Care Unit. J Racial Ethn Health Disparities 3:365-72
Murphy, T E; Van Ness, P H; Araujo, K L B et al. (2016) An Empirical Method of Detecting Time-Dependent Confounding: An Observational Study of Next Day Delirium in a Medical ICU. Int J Stat Med Res 5:41-47
Han, Ling; Pisani, M A; Araujo, K L B et al. (2016) Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients. Int J Stat Med Res 5:8-16
Ahasic, Amy M; Van Ness, Peter H; Murphy, Terrence E et al. (2015) Functional status after critical illness: agreement between patient and proxy assessments. Age Ageing 44:506-10
Pisani, Margaret A; Araujo, Katy L B; Murphy, Terrence E (2015) Association of cumulative dose of haloperidol with next-day delirium in older medical ICU patients. Crit Care Med 43:996-1002
Pisani, Margaret A; Bramley, Kyle; Vest, Michael T et al. (2013) Patterns of opiate, benzodiazepine, and antipsychotic drug dosing in older patients in a medical intensive care unit. Am J Crit Care 22:e62-9
Jones, Shirley F; Pisani, Margaret A (2012) ICU delirium: an update. Curr Opin Crit Care 18:146-51
Vest, Michael T; Murphy, Terrence E; Araujo, Katy L B et al. (2011) Disability in activities of daily living, depression, and quality of life among older medical ICU survivors: a prospective cohort study. Health Qual Life Outcomes 9:9
Murphy, Terrence E; Van Ness, Peter H; Araujo, Katy L B et al. (2011) Bayesian time-series analysis of a repeated-measures poisson outcome with excess zeroes. Am J Epidemiol 174:1230-7
Pisani, Margaret A; Murphy, Terrence E; Araujo, Katy L B et al. (2010) Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. J Crit Care 25:540.e1-7

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