This proposal details a five-year plan to provide the candidate, William Sheehan, MD, with the knowledge and expertise to become an independent investigator in the field of Allergy and Immunology. The proposed research project is centered on a novel strategy of evaluating the amount of detectable environmental peanut protein exposure in childhood environments, such as homes, schools, and preschools. It has recently been theorized that avoidance of foods at a young age has contributed to the rise in food allergies, because children were instead becoming sensitized by cutaneous exposure to small amounts of food proteins in the environment. Dr. Sheehan presents preliminary data demonstrating detectable amounts of peanut protein (Ara h 2) in schools and homes. The candidate will use the established infrastructure of his mentor, Dr. Wanda Phipatanakul (current NIAID-funded study entitled School and Inner City Asthma Study);to further explore the study of peanut protein in the environment by analyzing vacuumed dust and table wipe samples. In addition to evaluating homes and schools, peanut-free preschools serving very young children will also be evaluated. Additionally, Dr. Sheehan will evaluate the effect of this environmental peanut exposure on health outcomes. Specifically, he will investigate the effect of exposure to environmental peanut protein on asthma morbidity with a particular focus on children considered to be at the highest risk of being affected by this cutaneous exposure. The """"""""at risk"""""""" group will be defined by an enrolled subject with any one of the following conditions: (1) peanut allergy, (2) eczema, or (3) filaggrin gene mutation. Dr. Sheehan will work under the mentorship of Dr. Phipatanakul, an expert in environmental exposures and the relationship with allergic diseases. Dr. Sheehan has also assembled a team of extraordinary researchers, including Drs. Diane Gold, Raif Geha, and Brent Coull, who have committed their time, resources, and expertise to facilitate his career development and research goals. During the period of support for the candidate, he will engage in formal education on clinical research by obtaining a Master of Medical Sciences (MMSc) degree from the Scholars in Clinical Science Program at Harvard Medical School. This program will provide him with further skills in advanced biostatistics, epidemiology, clinical study design, clinical genetics, and scientific writing. Under the guidance of his primary mentor and collaborative team, in an ideal scientific and clinical environment at Boston Children's Hospital, the research project and career development plan will position the candidate to secure independent NIH funding and to establish himself as an independent clinical researcher in the field of environmental food exposures and allergic diseases, a relatively neglected area of investigation.
The prevalence of food allergies has risen greatly in recent years, including the rate of peanut allergy more than tripling in the past two decades. The exact cause of this increase is unknown, but it has been recently theorized that exposure to small amounts of these foods in the environment can lead to allergic sensitization and the development of food allergies in young children. In this proposal, we present a strategy of evaluating the exact amount of childhood environmental peanut protein exposure in homes, schools, and preschools and we explore possible health effect associated with this exposure.
| Jackson, Daniel J; Bacharier, Leonard B; Mauger, David T et al. (2018) Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. N Engl J Med 378:891-901 |
| Lai, Peggy S; Kolde, Raivo; Franzosa, Eric A et al. (2018) The classroom microbiome and asthma morbidity in children attending 3 inner-city schools. J Allergy Clin Immunol 141:2311-2313 |
| Morris, Claudia R; Mauger, David T; Suh, Jung H et al. (2018) Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation? J Allergy Clin Immunol 142:308-311.e9 |
| Gaffin, Jonathan M; Hauptman, Marissa; Petty, Carter R et al. (2018) Nitrogen dioxide exposure in school classrooms of inner-city children with asthma. J Allergy Clin Immunol 141:2249-2255.e2 |
| Sheehan, William J; Gaffin, Jonathan M; Peden, David B et al. (2017) Advances in environmental and occupational disorders in 2016. J Allergy Clin Immunol 140:1683-1692 |
| Dilley, Meredith A; Sheehan, William J; Petty, Carter R et al. (2017) Comparison of treatment modalities for inpatient asthma exacerbations among US pediatric hospitals. J Allergy Clin Immunol Pract 5:855-857.e1 |
| Sheehan, William J; Brough, Helen A; Makinson, Kerry et al. (2017) Distribution of peanut protein in school and home environments of inner-city children. J Allergy Clin Immunol 140:1724-1726 |
| Phipatanakul, Wanda; Koutrakis, Petros; Coull, Brent A et al. (2017) The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned. Contemp Clin Trials 60:14-23 |
| Dilley, Meredith A; Petty, Carter R; Sheehan, William J et al. (2017) Adherence and stress in a population of inner-city children with asthma. Pediatr Allergy Immunol 28:610-612 |
| Bartnikas, Lisa M; Huffaker, Michelle F; Sheehan, William J et al. (2017) Impact of school peanut-free policies on epinephrine administration. J Allergy Clin Immunol 140:465-473 |
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