This K23 mentored patient-oriented research application will support the career development of the candidate in the area of nicotine dependence and tobacco control, particularly targeting smoking cessation efforts to the ethnic minority populations. Drs. Sharon Hall and Neal Benowitz of the University of California, San Francisco will serve as the primary and secondary mentors. The objective for this 5-year proposed program is to provide training and hands-on experience in designing and conducting clinical trials, cross-cultural research and methodology, and clinical pharmacology knowledge and applications. The overall goal of this research is to design and test efficacious smoking cessation programs that can successfully treat a large minority group, Chinese American smokers. This study will transfer the interactive expert system technology in smoking cessation to Chinese American smokers and test the efficacy of the intervention using a randomized clinical trial in this population. It will also examine the effectiveness of proactive versus reactive recruitment approaches, which will guide implementation of smoking cessation intervention in this population. Participants will be randomized to either to a control condition receiving a standard self-help manual, or experimental condition receiving a stage-matched manual and 3 personalized expert-system reports over 6 months. Assessments will occur before randomization at baseline, 3, 6, 12, and 18 months. It is hypothesized that research participants receiving the experimental smoking cessation intervention will be more likely to be abstinent, report at least one quit attempt, and to significantly reduce in smoking rate (verified by continine) than those in the control condition at 12 and 18 months. The proactive recruitment approach is hypothesized to be more effective in reaching smokers who are not ready to quit smoking. Depression symptoms, negative affect, acculturation and gender differences in association with smoking behaviors and nicotine dependence in the Chinese population will be examined. Pilot work focusing on enhancing smoking intervention for this population will be conducted based on the findings of the proposed clinical trial. This research and career development program will yield significant knowledge for effectively treating Chinese American smokers, and will build a solid foundation to prepare the candidate to be an independent clinical research scientist.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23DA000468-01
Application #
6093717
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
Project Start
2000-08-16
Project End
2005-07-31
Budget Start
2000-08-16
Budget End
2001-07-31
Support Year
1
Fiscal Year
2000
Total Cost
$125,024
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Cheng, Kai-Wen; Tsoh, Janice Y; Cui, Wenlong et al. (2015) Smoking intensity among male factory workers in Kunming, China. Asia Pac J Public Health 27:NP606-15
Yamada, Hiroyuki; Acton, G Scott; Tsoh, Janice Y (2009) Differential item functioning of the English and Chinese versions of the Fagerstrom Test for Nicotine Dependence. Addict Behav 34:125-33
Kanneganti, Praveen; Huestis, Marilyn A; Kolbrich, Erin A et al. (2008) Signal-averaged electrocardiogram in physically healthy, chronic 3,4-methylenedioxymethamphetamine (MDMA) users. Am J Drug Alcohol Abuse 34:712-20
Kolbrich, Erin A; Goodwin, Robert S; Gorelick, David A et al. (2008) Physiological and subjective responses to controlled oral 3,4-methylenedioxymethamphetamine administration. J Clin Psychopharmacol 28:432-40
Kelly, Tamsin; Gray, Teresa R; Huestis, Marilyn A (2008) Development and validation of a liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry method for simultaneous analysis of 10 amphetamine-, methamphetamine- and 3,4-methylenedioxymethamphetamine-related (MDMA) analytes in J Chromatogr B Analyt Technol Biomed Life Sci 867:194-204
De Martinis, Bruno S; Barnes, Allan J; Scheidweiler, Karl B et al. (2007) Development and validation of a disk solid phase extraction and gas chromatography-mass spectrometry method for MDMA, MDA, HMMA, HMA, MDEA, methamphetamine and amphetamine in sweat. J Chromatogr B Analyt Technol Biomed Life Sci 852:450-8
Schmitt, Eva M; Tsoh, Janice Y; Dowling, Glenna A et al. (2005) Older adults' and case managers' perceptions of smoking and smoking cessation. J Aging Health 17:717-33
Prochaska, Judith J; Rossi, Joseph S; Redding, Colleen A et al. (2004) Depressed smokers and stage of change: implications for treatment interventions. Drug Alcohol Depend 76:143-51
Tsoh, Janice Y; Hall, Sharon M (2004) Depression and smoking: from the Transtheoretical Model of change perspective. Addict Behav 29:801-5
Tsoh, Janice Y; Lam, Judy N; Delucchi, Kevin L et al. (2003) Smoking and depression in Chinese Americans. Am J Med Sci 326:187-91

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