Nicotine dependence is very common among psychiatric patients and impacts clinical course, medication levels, and physical health of smokers. Unfortunately, there is a paucity of research for this subgroup of smokers and minimal treatment studies. The goals of this NIDA Mentored Patient-Oriented Research Career Development Award (K23) are to become an independent clinical researcher and create a program of research in the area of nicotine dependence and psychiatric comorbidity. This includes further training in Epidemiology and Quantitative Methods including research methodology, biostatistics and biocomputing, experiment design, process research and comorbidity issues. The UMDNJ-Robert Wood Johnson Medical School and the Rutgers Center for Alcohol Studies provide an excellent environment for developing research investigators. The primary mentor, Douglas Ziedonis, had extensive research experience, a NIDA Career Award, and is a leading psychiatrist studying nicotine dependence among individuals with schizophrenia. The research plan includes two studies. 1: Pharmacotherapy for Nicotine Dependence Among Psychiatric Patients. During a six-month study, schizophrenic smokers will be recruited into a double blind study comparing multiple doses of nicotine replacement pact .schizophrenics are believed to be more heavily dependent on nicotine, therefore, higher dose strategies and longer duration of treatment may yield greater quit rates. Study 2: Psychosocial Treatment for Nicotine Dependence Among Psychiatric Patients. Using NIDA stage a Behavioral Therapy approach, the specific aims of this study are to develop patient and clinical manuals, create adherence and rating scales and formalize a training program for clinicians and conduct a pilot study. Schizophrenics have unique disabilities in processing information and interpersonal communications that require specific and tailored therapies. Techniques from dual diagnosis treatment can be adapted for treating nicotine dependence and include aspects of social skills training, motivational enhancement therapy and relapse prevention.
| Williams, Jill M; Zimmermann, Mia Hanos; Steinberg, Marc L et al. (2011) A comprehensive model for mental health tobacco recovery in new jersey. Adm Policy Ment Health 38:368-83 |
| Gandhi, Kunal K; Williams, Jill M; Menza, Matthew et al. (2010) Higher serum caffeine in smokers with schizophrenia compared to smoking controls. Drug Alcohol Depend 110:151-5 |
| Williams, Jill M; Steinberg, Marc L; Zimmermann, Mia Hanos et al. (2010) Comparison of two intensities of tobacco dependence counseling in schizophrenia and schizoaffective disorder. J Subst Abuse Treat 38:384-93 |
| Galazyn, Magdalena; Steinberg, Marc L; Gandhi, Kunal K et al. (2010) Reasons for smoking among individuals with schizophrenia. Schizophr Res 122:268-9 |
| Williams, Jill M; Gandhi, Kunal K; Karavidas, Maria Katsamanis et al. (2008) Open-Label Study of Craving in Smokers With Schizophrenia Using Nicotine Nasal Spray Compared to Nicotine Patch. J Dual Diagn 4:355-376 |
| Williams, Jill M; Foulds, Jonathan; Dwyer, Martha et al. (2005) The integration of tobacco dependence treatment and tobacco-free standards into residential addictions treatment in New Jersey. J Subst Abuse Treat 28:331-40 |
| Steinberg, Marc L; Williams, Jill M; Steinberg, Howard R et al. (2005) Applicability of the Fagerstrom Test for Nicotine Dependence in smokers with schizophrenia. Addict Behav 30:49-59 |
| Williams, Jill M; Ziedonis, Douglas (2004) Addressing tobacco among individuals with a mental illness or an addiction. Addict Behav 29:1067-83 |
| Steinberg, M L; Williams, J M; Ziedonis, D M (2004) Financial implications of cigarette smoking among individuals with schizophrenia. Tob Control 13:206 |
| Williams, Jill M; Ziedonis, Douglas M; Foulds, Jonathan (2004) A case series of nicotine nasal spray in the treatment of tobacco dependence among patients with schizophrenia. Psychiatr Serv 55:1064-6 |
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