This K23 award would advance Dr. Wolfsdorf's long-term goal to become an independent scientist, investigating the ubiquitous implications of affect dysregulation and coping for treatment of patients with mood, substance-use, and trauma-related disorders, and developing efficacious treatments for these patients. It would also facilitate the research productivity required to advance to the rank of Associate Professor within the next 5 years. The proposed research will enable Dr. Wolfsdorf to achieve the immediate goal of acquiring a rich patient-oriented data set addressing psychiatric diagnosis, affect dysregulation, and coping in the maintenance of nicotine dependence within a psychiatric population. These data will inform future treatment development, and provide a basis on which to pursue R01 grant funding. Dr. Wolfsdorf's multidisciplinary mentoring team, comprised of Drs. Gulliver (primary mentor), Ciraulo (departmental mentor), and Garvey (off-site mentor) will facilitate her goals. Each mentor brings unique strengths to the team in patient-oriented research, methodology and design, data management and analyses, and ethics. Dr. Wolfsdorf's career plan includes individual meetings with each, and well as larger science meetings and selected course work in advanced statistics and ethics. The Boston University School of Medicine, Boston VA, and mentors, have long and productive histories of mentorship and the facilities and resources to support Dr. Wolfsdorf in her pursuits.
The specific aim of this two-cell, quasi-experimental investigation is to increase the understanding of differential smoking-cessation success among two groups of psychiatric smokers - successful quitters and current smokers in terms of diagnosis, and mood-, coping-, and smoking-related variables at baseline, after a stressor, and at 3- and 6- month follow-up. Psychiatric status and mood-, coping-, and smoking-related variables will be assessed using semi-structured interviews, self-report measures, and physiological measures (CO and cotinine) at baseline. Following an experimental stressor (adapted mental arithmetic test) participants will again complete measures of mood- and smoking-related variables (including a manipulation test). Three- and six-month follow-up assessments of smoking status, nicotine dependence, self-reported quit attempts, and psychiatric severity will be conducted.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DA016138-02
Application #
6727656
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Aigner, Thomas G
Project Start
2003-06-01
Project End
2008-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
2
Fiscal Year
2004
Total Cost
$134,029
Indirect Cost
Name
Boston University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Ciraulo, Domenic A; Barlow, David H; Gulliver, Suzy Bird et al. (2013) The effects of venlafaxine and cognitive behavioral therapy alone and combined in the treatment of co-morbid alcohol use-anxiety disorders. Behav Res Ther 51:729-35
Hitsman, Brian; Shen, Biing-Jiun; Cohen, Ronald A et al. (2010) Measuring smoking-related preoccupation and compulsive drive: evaluation of the obsessive compulsive smoking scale. Psychopharmacology (Berl) 211:377-87
Davila, Joanne; Kamholz, Barbara Wolfsdorf; Rayburn, Nadine Recker et al. (2006) Perspectives on nontraditional research careers in clinical psychology. J Clin Psychol 62:907-21
Gulliver, Suzy Bird; Kamholz, Barbara W; Helstrom, Amy W (2006) Smoking cessation and alcohol abstinence: what do the data tell us? Alcohol Res Health 29:208-12
Buckley, Todd C; Kamholz, Barbara Wolfsdorf; Mozley, Susannah L et al. (2005) A psychometric evaluation of the Smoking Consequences Questionnaire-Adult in smokers with psychiatric conditions. Nicotine Tob Res 7:739-45