Nicotine Dependence is a substantial problem for individuals with serious unique mental illness. The biopsychosocial problems of individuals with schizophrenia and the realities of the current mental health system have somehow shielded this population from the benefits of tobacco control efforts to better engage these heavy smokers into nicotine dependence treatment. This K23 Award is necessary to provide the candidate with the required time, resources, and additional training to further his patient oriented research interests in better understanding how to engage and treat nicotine dependence in smokers with schizophrenia. The proposed Primary Mentor (Douglas Ziedonis) and the UMDNJ/Rutgers environment offers much to help the applicant achieve his goal of becoming an independent researcher. The research plan includes two studies that seek to further evaluate why so few smokers with schizophrenia quit compared to the general population and to develop interventions to engage this population into tobacco dependence treatment. The first study is a Patient-Oriented Laboratory Study that will a) Compare levels of task persistence, cognition, and motivation in smokers with and without schizophrenia, and b) Evaluate task persistence as a partial mediator of psychiatric status and nicotine dependence treatment outcome. An additional reason smokers with schizophrenia may be less likely to quit smoking may be related to their motivation to make a quit attempt. The second study is a Stage 1 a/b Behavioral Therapy Development Study that will build on the candidate's prior research on enhancing motivation to seek nicotine dependence treatment. The primary aims include a) Further develop a computerized personal feedback assessment, b) Further develop an impact scale of feedback items, c) Create a therapy manual, adherence scale, training program, and randomized study to determine the appropriate effect size with which to power a future Stage II study. The training plan aims to complement the research plan and advance the candidate's professional skills. The plan will include important hands-on learning experiences, workshops, class work, attendance at national scientific conferences, and strong mentoring relationships.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DA018203-04
Application #
7242600
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Subramaniam, Geetha A
Project Start
2004-09-30
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
4
Fiscal Year
2007
Total Cost
$146,589
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Psychiatry
Type
Schools of Medicine
DUNS #
617022384
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Steinberg, Marc L; Williams, Jill M; Stahl, Naomi F et al. (2016) An Adaptation of Motivational Interviewing Increases Quit Attempts in Smokers With Serious Mental Illness. Nicotine Tob Res 18:243-50
Steinberg, Marc L; Williams, Jill M (2013) State, but not trait, measures of persistence are related to negative affect. J Stud Alcohol Drugs 74:584-8
Steinberg, Marc L; Williams, Jill M; Gandhi, Kunal K et al. (2012) Task persistence predicts smoking cessation in smokers with and without schizophrenia. Psychol Addict Behav 26:850-8
Williams, Jill M; Zimmermann, Mia Hanos; Steinberg, Marc L et al. (2011) A comprehensive model for mental health tobacco recovery in new jersey. Adm Policy Ment Health 38:368-83
Steinberg, Marc L; Williams, Jill M; Gandhi, Kunal K et al. (2010) Lower task persistence in smokers with schizophrenia as compared to non-psychiatric control smokers. Psychol Addict Behav 24:724-9
Williams, Jill M; Steinberg, Marc L; Zimmermann, Mia Hanos et al. (2010) Comparison of two intensities of tobacco dependence counseling in schizophrenia and schizoaffective disorder. J Subst Abuse Treat 38:384-93
Galazyn, Magdalena; Steinberg, Marc L; Gandhi, Kunal K et al. (2010) Reasons for smoking among individuals with schizophrenia. Schizophr Res 122:268-9
Steinberg, Marc L; Heimlich, Laura; Williams, Jill M (2009) Tobacco use among individuals with intellectual or developmental disabilities: a brief review. Intellect Dev Disabil 47:197-207
Steinberg, Marc L; Krejci, Jonathan A; Collett, Kerstin et al. (2007) Relationship between self-reported task persistence and history of quitting smoking, plans for quitting smoking, and current smoking status in adolescents. Addict Behav 32:1451-60
Williams, Jill M; Gandhi, Kunal K; Steinberg, Marc L et al. (2007) Higher nicotine and carbon monoxide levels in menthol cigarette smokers with and without schizophrenia. Nicotine Tob Res 9:873-81