Over-prescribed opioids after surgery can create a reservoir of opioids that become available for non-medical use. Effective strategies to maximize non-opioid pain therapy and to limit such a reservoir are lacking. Thus, there is an urgent need to study opioid usage patterns and to individualize post-operative pain therapy. The rationale that underlies the proposed research is that once we better understand post-discharge opioid use patterns, we can improve pain management and significantly decrease unnecessarily prescribed opioids. Our central hypothesis is that pain therapy after surgery can be prescribed in an individualized and safer fashion, as opposed to ?one size fits all? or non-data driven methods currently employed. To test our hypothesis, three aims are proposed:
Specific aim #1 will examine the relationship between patient and procedural characteristics and long-term opioid prescriptions after surgery. This retrospective cohort study includes 6442 patients and will utilize both clinical and claims-based databases.
Specific aim #2 will examine patient and procedural characteristics to assess post-operative pain outcomes and predict use patterns for opioids prescribed after surgery. Using survey methods, we will assess pain intensity and interference and quantify consumption of opioids in 600 patients after surgery. A model to predict high vs. low use of prescribed opioids will be developed.
Specific aim #3 will prospectively test a decision support tool integrated into the electronic medical record in 116 surgical patients after hospital discharge. The tool will predict actual need for opioid medications and empower patients to maximize non-opioid analgesics. Limiting excess prescription of opioids and maximizing non-opioid medications has the potential to dramatically reduce the amount of opioids available for non-medical use while improving post-operative pain control. The applicant, an anesthesiologist with subspecialty training in pain medicine, proposes a five-year career development program to compliment the research proposal. This incorporates close mentoring by a well-established investigator with expertise in preventing medical complications of drug use in high-risk populations. A mentoring team composed of key faculty members with expertise in psychiatric perspectives of addiction, biostatistics, and health information technology will support the primary mentor. In addition, the candidate has developed a detailed didactic plan that includes training in specialty knowledge in opioid use disorders, epidemiology, health information technology, and clinical trials. The candidate's long-term goal is to develop into an independent clinical scientist with expertise in drug abuse and emphasis on safe and effective delivery of pain therapy after surgery The proposed research, which serves as the key first step towards the applicant reaching his long-term goal, is significant because it will fill the existing gaps in knowledge to curb the United States opioid epidemic and enhance postoperative pain management.
Prescription opioid overdoses are a leading cause of death in the United States. The proposed research aims at developing patient-centered prescribing practices for pain therapy after surgery. Limiting excess prescription of opioids for use after discharge, while improving post-operative pain control, has the potential to substantially reduce the amount of opioids available for non-medical use and subsequently reduce the number of prescription opioid deaths.
| Kuhn, Sven-Olaf; Meissner, Konrad; Mayes, Lena M et al. (2018) Vitamin C in sepsis. Curr Opin Anaesthesiol 31:55-60 |
| Mayes, Lena M; Wong, Cynthia A; Zimmer, Shanta et al. (2018) Gender differences in career development awards in United States' anesthesiology and surgery departments, 2006-2016. BMC Anesthesiol 18:95 |
| Bartels, Karsten; Fernandez-Bustamante, Ana; McWilliams, Shannon K et al. (2018) Long-term opioid use after inpatient surgery - A retrospective cohort study. Drug Alcohol Depend 187:61-65 |
| Merkow, Justin S; Hoerauf, Janine M; Moss, Angela F et al. (2018) Animal experimental research design in critical care. BMC Med Res Methodol 18:71 |
| Hoerauf, Janine M; Moss, Angela F; Fernandez-Bustamante, Ana et al. (2018) Study Design Rigor in Animal-Experimental Research Published in Anesthesia Journals. Anesth Analg 126:217-222 |
| Henthorn, Thomas K; Mikulich-Gilbertson, Susan K (2018) ?-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain? Anesthesiology 128:867-870 |
| Brainard, Jason; Scott, Benjamin K; Sullivan, Breandan L et al. (2017) Heated humidified high-flow nasal cannula oxygen after thoracic surgery - A randomized prospective clinical pilot trial. J Crit Care 40:225-228 |
| Bartels, Karsten; Meissner, Konrad (2017) Morphine and the blood-brain barrier: diffusion, uptake, or efflux? Can J Anaesth 64:997-1001 |
| Morabito, Joseph; Bell, Marshall T; Montenij, Leon J et al. (2017) Perioperative Considerations for Chylothorax. J Cardiothorac Vasc Anesth 31:2277-2281 |
| Fernandez-Bustamante, Ana; Frendl, Gyorgy; Sprung, Juraj et al. (2017) Postoperative Pulmonary Complications, Early Mortality, and Hospital Stay Following Noncardiothoracic Surgery: A Multicenter Study by the Perioperative Research Network Investigators. JAMA Surg 152:157-166 |
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